HETEROGENEITY OF BLOOD-BRAIN-BARRIER CHANGES IN MULTIPLE-SCLEROSIS - AN MRI STUDY WITH GADOLINIUM-DTPA ENHANCEMENT
HETEROGENEITY OF BLOOD-BRAIN-BARRIER CHANGES IN MULTIPLE-SCLEROSIS - AN MRI STUDY WITH GADOLINIUM-DTPA ENHANCEMENT
复制标题
DOI：
10.1212/wnl.40.2.229
复制
发表时间：
1990-02-01
期刊：
影响因子：
9.9
通讯作者：
MCDONALD, WI
中科院分区：
文献类型：
--
作者：
KERMODE, AG;TOFTS, PS;MCDONALD, WI
我们对8例复发和缓解型多发性硬化症患者进行了15次动态钆-DTPA（Gd-DTPA）增强MRI研究; 7例为随访研究。我们测量了102个增强病灶的增强时间过程，最长为384分钟，休息休息。增强后即刻MRI显示了许多不同的增强模式。我们观察到均匀增强和环形增强的病灶。增强区的范围通常小于T2加权像上相应的高信号。Gd-DTPA检查发现3处病变，但未在非增强扫描中发现; 10天后，在非增强扫描中发现1处病变，这表明血脑屏障障碍可能先于MS病变的其他MRI体征。三个月后，T2加权扫描上的一些高信号区域的大小已经减少，与先前Gd-DTPA概述的区域相似。该技术提供了关于MS病变的发病机制和行为的有用信息。
We performed 15 dynamic gadolinium-DTPA (Gd-DTPA)-enhanced MRI studies in 8 patients with relapsing and remitting multiple sclerosis; 7 were follow-up studies. We measured the time course of enhancement in 102 enhancing lesions for up to 384 minutes, with rest breaks. Immediate postcontrast MRIs demonstrated many different patterns of enhancement. We observed uniformly enhancing and ring enhancing lesions. The enhancing regions were often less extensive than the corresponding high signal on T2-weighted images. Three lesions were seen with Gd-DTPA but not on unenhanced scans; 1 was seen on unenhanced scans 10 days later, suggesting that blood-brain barrier disturbance may precede other MRI signs of MS lesions. Three months later, some high-signal areas on T2-weighted scans had decreased in size to resemble the areas previously outlined by Gd-DTPA. This technique provides useful information about the pathogenesis and behavior of MS lesions.