Circadian variations in the rat serum total antioxidant status: Correlation with melatonin levels
Circadian variations in the rat serum total antioxidant status: Correlation with melatonin levels
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DOI：
10.1111/j.1600-079x.1998.tb00378.x
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发表时间：
1998-08-01
影响因子：
10.3
通讯作者：
Guerrero, JM
中科院分区：
文献类型：
--
作者：
Benot, S;Molinero, P;Guerrero, JM
在这篇论文中，我们首次展示了大鼠血清总抗氧化状态(TAS)的昼夜节律，这种节律与24-H褪黑素循环平行。大鼠血清TAS和褪黑激素均表现出24小时的变化，夜间峰值出现在05.00小时，白天基础值较低。在光照(~GT；500lux)下(20.00~05.00小时)，大鼠血清TAS明显低于黑暗中处死的对照组大鼠。此外，当动物在连续光照下持续暴露5天并在05小时处死时，血清TAS与对照组相比有进一步的下降。由于外源性褪黑素也增加了大鼠血清中的TAS，结果表明褪黑素可能与参与大鼠血清的抗氧化能力有关。
In this paper, we show for the first time, a nyctohemeral rhythm in serum total antioxidant status (TAS) in rats which parallels the 24-H melatonin cycle. Both TAS and melatonin in rat serum exhibited 24 hr variations with nocturnal peak values at 05.00 hr and low basal values during the day. When rats were maintained under light exposure (>500 lux) from 20.00 h to 05.00 hr, serum TAS was significantly reduced when compared with control rat killed in darkness. Moreover, when animals were maintained under continuous light exposure for 5 days and killed at 05.00 hr, serum TAS exhibited an additional decrease when compared with control rats. Since administering exogeneus melatonin also increased TAS in the rat serum, results suggest that melatonin may be relevant in terms of participating in the antioxidative capacity of the rat serum.