Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese
Associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and the metabolic syndrome in middle-aged and older Chinese
复制标题
中国中老年人红细胞棕榈油酸与脂肪因子、炎症标志物和代谢综合征的关系
DOI：
10.3945/ajcn.112.040204
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发表时间：
2012-11-01
影响因子：
7.1
通讯作者：
Lin, Xu
中科院分区：
文献类型：
--
作者：
Zong, Geng;Ye, Xingwang;Lin, Xu
背景：动物研究显示棕榈油酸可调节脂肪因子表达和全身代谢稳态。然而，它与人类代谢疾病的关系仍存在争议。目的：我们旨在研究中国人群中红细胞棕榈油酸与脂肪因子、炎症标志物和代谢综合征（MetS）的关系。设计：对3107名年龄在50-70岁之间的男性和女性进行了基于人群的红细胞脂肪酸测定，对他们的血糖、胰岛素、血脂、脂联素、测定视黄醇结合蛋白4（RBP-4）、纤溶酶原激活物抑制剂1型和高敏C反应蛋白（hsCRP）。MetS是根据更新的亚裔美国人国家胆固醇教育计划成人治疗小组III标准定义的。结果：平均（+/- SD）红细胞棕榈油酸值为总脂肪酸的0.41 +/- 0.20%。棕榈油酸与RBP-4呈正相关（r = 0.14，P < 0.001），与脂联素呈负相关（r =-0.15，P < 0.001）。多变量校正后，棕榈油酸与MetS及其组分密切相关。棕榈油酸极端四分位数比较的OR（95% CI）为3.50（2.66，4.59）对于MetS，7.88（5.90，10.52）高脂血症，2.13（1.66，2.72），中心性肥胖组为1.99（1.60，2.48），血压升高组为1.86（1.41，2.44）（P均< 0.001）。脂肪因子和hsCRP的进一步控制取消了棕榈油酸与中心性肥胖，但不与其他代谢综合征components.Conclusion：红细胞棕榈油酸与脂肪因子和炎症标志物的不良反应和代谢综合征的风险增加，在这个中国人口。美国临床营养杂志2012;96：970-6.
Background: Palmitoleic acid has been shown to regulate adipokine expression and systemic metabolic homeostasis in animal studies. However, its association with human metabolic diseases remains controversial.Objective: We aimed to investigate associations of erythrocyte palmitoleic acid with adipokines, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population.Design: Erythrocyte fatty acids were measured in a population-based sample of 3107 men and women aged 50-70 y, for whom plasma glucose, insulin, lipid profile, adiponectin, retinol binding protein 4 (RBP-4), plasminogen activator inhibitor type 1, and high-sensitivity C-reactive protein (hsCRP) were measured. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.Results: The mean (+/- SD) erythrocyte palmitoleic acid value was 0.41 +/- 0.20% of total fatty acids. Palmitoleic acid was positively correlated with RBP-4 (r = 0.14, P < 0.001) and inversely correlated with adiponectin (r = -0.15, P < 0.001). After multivariable adjustment, palmitoleic acid was strongly associated with MetS and its components. ORs (95% CIs) for comparisons of extreme quartiles of palmitoleic acid were 3.50 (2.66, 4.59) for MetS, 7.88 (5.90, 10.52) for hypertriglyceridemia, 2.13 (1.66, 2.72) for reduced HDL cholesterol, 1.99 (1.60, 2.48) for central obesity, and 1.86 (1.41, 2.44) for elevated blood pressure (all P < 0.001). Further control for adipokines and hsCRP abolished the association of palmitoleic acid with central obesity but not with other MetS components.Conclusion: Erythrocyte palmitoleic acid is associated with an adverse profile of adipokines and inflammatory markers and an increased risk of MetS in this Chinese population. Am J Clin Nutr 2012;96:970-6.