"I feel empowered": women's perspectives on and experiences with long-acting injectable antiretroviral therapy in the USA and Spain
"I feel empowered": women's perspectives on and experiences with long-acting injectable antiretroviral therapy in the USA and Spain
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DOI：
10.1080/13691058.2020.1752397
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发表时间：
2020-05-20
影响因子：
2.2
通讯作者：
Kerrigan, Deanna
中科院分区：
文献类型：
--
作者：
Mantsios, Andrea;Murray, Miranda;Kerrigan, Deanna
临床试验表明，长效注射抗逆转录病毒疗法并不逊色于每日口服抗逆转录病毒疗法，并且可能很快成为临床护理的一部分。虽然迄今为止大多数试验参与者都是男性，但正在进行的 3 期试验参与者中约有四分之一是女性，这为了解女性如何看待和体验长效抗逆转录病毒治疗提供了重要的机会。我们对参加美国和西班牙长效抗逆转录病毒治疗 2 期和 3 期临床试验的 80 名 HIV 感染者进行了深入访谈。受访的试验参与者中有百分之十五 (12/80) 是女性。采访内容通过内容分析进行录音、转录和编码，重点关注特定性别的主题。女性与男性有着相同的许多积极看法，但也有独特的观点，包括发现长效抗逆转录病毒疗法解决了在忙碌的日常现实（包括多重角色和责任）中记住药物的挑战，与口服抗逆转录病毒疗法相比，耗时更少，产生的压力更小，并且可以释放情感并赋予权力。女性生活的性别特征决定了她们对长效抗逆转录病毒治疗的满意度和满意度。研究结果可以为干预措施和支持系统提供信息，以促进女性接受和坚持长效抗逆转录病毒治疗。
Long-acting injectable antiretroviral therapy has been shown to be non-inferior to daily oral antiretroviral therapy in clinical trials and may soon become part of clinical care. While most trial participants to date have been men, approximately one quarter of ongoing Phase 3 trial participants are women offering an important opportunity to understand how long-acting antiretroviral therapy is perceived and experienced by women. We conducted in-depth interviews with 80 people living with HIV participating in Phase 2 and 3 clinical trials of long-acting antiretroviral therapy in the USA and Spain. Fifteen percent (12/80) of trial participants interviewed were women. Interviews were audio-recorded, transcribed and coded using content analysis, focused on gender-specific themes. Women shared many of the positive perceptions expressed by men but also had unique perspectives, including finding that long-acting antiretroviral therapy addressed the challenge of remembering pills amidst busy day-to-day realities including multiple roles and responsibilities, is less time consuming and creates less stress compared to oral antiretroviral therapy, and is emotionally freeing and empowering. The gendered nature of women's lives shaped why and how they were satisfied with long-acting antiretroviral therapy. Findings can inform interventions and support systems to facilitate uptake of and adherence to long-acting antiretroviral therapy in women.