Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
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DOI：
10.1002/ejhf.203
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发表时间：
2015-02-01
影响因子：
18.2
通讯作者：
Pieske, Burkert M.
中科院分区：
文献类型：
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作者：
Edelmann, Frank;Holzendorf, Volker;Pieske, Burkert M.
AimsGalectin-3 是心肌纤维化的标志物，介导醛固酮诱导的心血管炎症和纤维化。半乳糖凝集素 3 的特性及其对螺内酯的反应尚未在射血分数保留的心力衰竭 (HFpEF) 中进行评估。本研究的目的是确定半乳糖凝集素 3 水平与 HFpEF 患者特征之间的关联；评估螺内酯和半乳糖凝集素 3 水平之间的相互作用；方法和结果Aldo-DHF 对 NYHA II-III 级、LVEF 50%、I 级舒张功能障碍和峰值 VO(2)25mL/kg/min 的患者进行了为期 12 个月的螺内酯 25mg 每日一次与安慰剂对比研究。 Galectin-3 水平在基线、6 个月和 12 个月时获得。评估了基线半乳糖凝集素 3、半乳糖凝集素 3 的变化与全因死亡或住院治疗之间的关联，并评估了半乳糖凝集素 3 与治疗之间的相互作用。半乳糖凝集素 3 基线中位数为 12.1 ng/mL。多变量调整后，基线半乳糖凝集素 3 与峰值 VO2 (P=0.021)(,) 6 分钟步行距离 (P=0.002) 和简式 36 (SF-36) 身体机能 (P=0.001) 呈负相关，并与 NYHA 分级直接相关 (P=0.007)。基线 NT-proBNP 与 E/e' 速度比 (P < 0.001)、左心房容积指数 (P
AimsGalectin-3 is a marker of myocardial fibrosis and mediates aldosterone-induced cardiovascular inflammation and fibrosis. Characteristics of galectin-3 and its response to spironolactone have not been evaluated in heart failure with preserved ejection fraction (HFpEF). The aim of this study was to determine the association between galectin-3 levels and patient characteristics in HFpEF; to evaluate the interaction between spironolactone and galectin-3 levels; and to assess the association between galectin-3 and clinical outcomes.Methods and resultsAldo-DHF investigated spironolactone 25mg once daily vs. placebo for 12 months in patients with NYHA class II-III, LVEF 50%, gradeI diastolic dysfunction, and peakVO(2)25mL/kg/min. Galectin-3 levels were obtained at baseline, and at 6 and 12 months. The association between baseline galectin-3, change in galectin-3, and all-cause death or hospitalization was evaluated, and the interaction between galectin-3 and treatment was assessed. Median baseline galectin-3 was 12.1ng/mL. After multivariable adjustment, baseline galectin-3 inversely correlated with peak VO2 (P=0.021)(,) 6min walk distance (P=0.002), and Short Form 36 (SF-36) physical functioning (P=0.001), and directly correlated with NYHA class (P=0.007). Baseline NT-proBNP correlated with E/e' velocity ratio (P 0.001), left atrial volume index (P