Are sirtuins viable targets for improving healthspan and lifespan?
Are sirtuins viable targets for improving healthspan and lifespan?
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Sirtuins是否可行的目标可以改善健康状态和寿命？
DOI：
10.1038/nrd3738
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发表时间：
2012-06-01
期刊：
影响因子：
--
通讯作者：
de Cabo R
中科院分区：
文献类型：
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作者：
Baur JA;Ungvari Z;Minor RK;Le Couteur DG;de Cabo R
尽管我们人口寿命的延长说明了现代医学的成功，但随着年龄的增长，患许多疾病的风险呈指数级增长。众所周知，热量限制可以延缓衰老，延缓功能衰退以及大多数生物体的疾病发作。研究表明sirtuins（SIRT 1-SIRT 7）是衰老过程中热量限制的关键影响的介质。两种不相关的分子，白藜芦醇和SRT 1720，已被证明在某些情况下增加SIRT 1的活性，是对哺乳动物代谢应激的优秀保护，使SIRT 1成为治疗干预的潜在吸引力的目标。本文综述了sirtuins作为新型药理学靶点的现状和争议，重点是SIRT 1。
Although the increased lifespan of our populations illustrates the success of modern medicine, the risk of developing many diseases increases exponentially with old age. Caloric restriction is known to retard ageing and delay functional decline as well as the onset of disease in most organisms. Studies have implicated the sirtuins (SIRT1–SIRT7) as mediators of key effects of caloric restriction during ageing. Two unrelated molecules that have been shown to increase SIRT1 activity in some settings, resveratrol and SRT1720, are excellent protectors against metabolic stress in mammals, making SIRT1 a potentially appealing target for therapeutic interventions. This Review covers the current status and controversies surrounding the potential of sirtuins as novel pharmacological targets, with a focus on SIRT1.