Neural correlates of instrumental learning in primary auditory cortex
Neural correlates of instrumental learning in primary auditory cortex
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DOI：
10.1073/pnas.092278099
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发表时间：
2002-07-23
影响因子：
11.1
通讯作者：
Merzenich, MM
中科院分区：
文献类型：
--
作者：
Blake, DT;Strata, F;Merzenich, MM
在工具性学习中，桑代克效应定律指出，刺激-反应关系如果发生在积极强化之前，则被强化；如果刺激反应关系发生在负强化之前，则被削弱。在这项研究中，我们证明了桑代克定律的神经关联可以在初级听觉皮质A1观察到。成年猫头鹰猴子学会了辨别高于标准频率的音调。从植入的微电极记录的响应最初在四到五倍频程范围内显示出广泛的光谱选择性。随着训练的进行，频率辨别阈值从接近一个八度改变到大约1/12个八度。在猴子受到行为控制的一周内，通过测量阈值的下降发出信号的生理记录对所有频率都有更强的反应。在同一周，相对于标准刺激和非目标刺激，A1神经对目标刺激的反应增加。在接下来的几周行为训练中，这种反应能力上的明显差异持续存在。这些数据表明，对刺激的行为反应调节了初级皮质区域的反应。
In instrumental learning, Thorndike's law of effect states that stimulus-response relations are strengthened if they occur prior to positive reinforcement and weakened if they occur prior to negative reinforcement. In this study, we demonstrate that neural correlates of Thorndike's law may be observed in the primary auditory cortex, A1. Adult owl monkeys learned to discriminate tones higher than a standard frequency. Responses recorded from implanted microelectrodes initially exhibited broad spectral selectivity over a four-to-five octave range. With training, frequency discrimination thresholds changed from close to one octave to about 1/12 octave. Physiological recordings during the week in which the monkey came under behavioral control signaled by a drop in measured threshold had stronger responses to all frequencies. During the same week, A1 neural responses to target stimuli increased relative to standard and nontarget stimuli. This emergent difference in responsiveness persisted throughout the subsequent weeks of behavioral training. These data suggest that behavioral responses to stimuli modulate responsiveness in primary cortical areas.