GENETIC AND ENVIRONMENTAL-INFLUENCES ON PREMATURE DEATH IN ADULT ADOPTEES
GENETIC AND ENVIRONMENTAL-INFLUENCES ON PREMATURE DEATH IN ADULT ADOPTEES
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DOI：
10.1056/nejm198803243181202
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发表时间：
1988-03-24
影响因子：
158.5
通讯作者：
TEASDALE, TW
中科院分区：
文献类型：
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作者：
SORENSEN, TIA;NIELSEN, GG;TEASDALE, TW
为了评估遗传和环境对成人死亡率的影响，我们跟踪了960个家庭，其中包括1924年至1926年期间出生的儿童，这些儿童在生命早期被安置在与他们无关的养父母那里。我们评估了16至58岁之间因各种原因或特定原因死亡的风险，这些原因是被收养者的亲生父母或养父母在50岁或70岁之前死于同一原因。我们将这些风险与被收养者在16岁至48岁之间死于相同原因的风险进行了比较，当时生物学或养父母在50岁和70岁时仍然活着。亲生父母在50岁之前死亡导致被收养者死亡的相对风险为1.71（95%置信区间，1.14至2.57）对于所有原因，1.98（1.25 ~ 3.12），感染5.81（2.47 ~ 13.7），心脑血管4.52（1.32 ~ 15.4），癌症1.19（0.16 ~ 8.99）。养父母的死亡导致被收养者的相对死亡风险接近于所有原因，自然原因和感染的统一，血管原因为3.02（0.72至12.8），癌症为5.16（1.20至22.2）。当亲生父母或养父母在70岁之前死亡时，观察到类似但较弱的模式。我们的结论是，成年人的过早死亡有很强的遗传背景，尤其是由于感染和血管原因导致的死亡。相比之下，癌症死亡，也可能是血管原因，似乎受到家庭环境的影响。
To assess genetic and environmental influences on adult mortality, we followed 960 families that included children born during the period 1924 through 1926 who were placed early in life with adoptive parents unrelated to them. We evaluated the risk of dying from all causes or from specific groups of causes between the ages of 16 and 58 years for adoptees with a biologic or adoptive parent who died of the same cause before the age of either 50 or 70. We compared these risks with the adoptees'' risk of dying from the same causes between the ages of 16 and 48 when either the biologic or adoptive parents were still alive at the age of 50 and 70. The death of a biologic parent before the age of 50 resulted in relative risks of death in the adoptees of 1.71 (95 percent confidence interval, 1.14 to 2.57) for all causes, 1.98 (1.25 to 3.12) for natural causes, 5.81 (2.47 to 13.7) for infections 4.52 (1.32 to 15.4) for cardiovascular and cerebrovascular causes, and 1.19 (0.16 to 8.99) for cancers. The death of an adoptive parent resulted in relative risks of death in the adoptees that were close to unity for all causes, natural causes, and infections, 3.02 (0.72 to 12.8) for vascular causes, and 5.16 (1.20 to 22.2) for cancers. A similar but weaker pattern was observed when either a biologic or adoptive parent died before the age of 70. We conclude that premature death in adults has a strong genetic background.sbd.especially death due to infections and vascular causes. In contrast, death from cancer, and possibly also from vascular causes, appears to be influenced by the family environment.