High-contrast mapping of basal cell carcinomas
High-contrast mapping of basal cell carcinomas
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DOI：
10.1364/ol.37.000644
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发表时间：
2012-02-15
期刊：
影响因子：
3.6
通讯作者：
Neel, Victor
中科院分区：
文献类型：
--
作者：
Yaroslavsky, Anna N.;Patel, Rakesh;Neel, Victor
由于可见光谱范围内的光学对比度较低，基底细胞癌 (BCC) 的准确检测仍然是一个具有挑战性的问题。在这封信中，我们通过实验证明，1300 nm 附近的反射共焦成像可用于无需外源造影剂的 BCC 检测。我们展示了具有清晰轮廓的癌症的厚新鲜皮肤组织的高对比度反射共焦图像，并讨论了导致 BCC 散射减少的可能原因。与组织病理学的比较证实，与良性皮肤结构相比，肿瘤分散较少，并且在图像中表现出较低的像素值。结果证明了利用肿瘤和正常皮肤之间散射的内在差异实时无创检测基底细胞癌的可行性。 (C) 2012年美国光学学会
Because of low optical contrast in the visible spectral range, accurate detection of basal cell carcinomas (BCC) remains a challenging problem. In this letter, we experimentally demonstrate that reflectance confocal imaging in the vicinity of 1300 nm can be used for the detection of BCC without exogenous contrast agents. We present high- contrast reflectance confocal images of thick fresh skin tissues with clearly delineated cancer and discuss possible reasons for causing decreased scattering of BCC. Comparison with histopathology confirms that tumors scatter less and exhibit lower pixel values in the images, as compared to benign skin structures. The results demonstrate the feasibility of real- time noninvasive detection of BCC using intrinsic differences in scattering between tumors and normal skin. (C) 2012 Optical Society of America