Mechanical evaluation of a porous bone graft substitute based on poly(propylene glycol-co-fumaric acid).
Mechanical evaluation of a porous bone graft substitute based on poly(propylene glycol-co-fumaric acid).
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基于聚（丙二醇-富马酸）的多孔骨移植替代物的机械评估。
DOI：
10.1002/jbm.b.10011
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Trantolo,DebraJ
中科院分区：
文献类型：
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作者：
Hile,DavidD;Kirker-Head,Carl;Doherty,StephenA;Kowaleski,MichaelP;McCool,John;Wise,DonaldL;Trantolo,DebraJ
对基于聚（丙二醇-共-富马酸）（PPF）的多孔可吸收聚合物复合材料作为骨移植替代物和骨折固定剂进行了体外力学评价。试验材料创建了一个动态系统，能够初始为骨空隙提供机械完整性，并通过天然骨长入提供降解机制。不饱和聚合物，PPF，在交联剂的存在下交联，固化后产生多孔的微观结构。一项体外降解研究首先评估了试验材料的时间机械性能。本研究之后进行了一项使用长骨截骨模型表征固定力学的体外研究。结果表明，交联PPF系统的初始抗压强度与松质骨相当。强度损失率与愈合骨的预测机械恢复相当，在也包含25%（按重量计）自体移植物的复合材料中具有类似结果。在长骨模型中进行的力学测试表明，PPF基骨移植物替代材料可增加克氏针稳定截骨术的弯曲强度。这些结果表明，这种类型的骨移植替代物在复杂管状骨折的稳定中可能具有临床实用性。© 2003 Wiley Periodicals，Inc.生物医学材料研究杂志B部分：应用生物材料66 B：311-317，2003
A porous, resorbable polymer composite based on poly(propylene glycol‐co‐fumaric acid) (PPF) was mechanically evaluatedin vitrofor use as a bone graft substitute and fracture fixative. The test material created a dynamic system capable of initially providing mechanical integrity to bony voids and a degradative mechanism for ingrowth by native bone. The unsaturated polymer, PPF, was crosslinked in the presence of effervescent agents to yield a porous microstructure upon curing. Anin vitrodegradation study first assessed the temporal mechanical properties of the test material. This research was followed by anex vivostudy using a long‐bone osteotomy model to characterize the mechanics of fixation. Results showed the initial compressive strength of the cross‐linked PPF system was comparable to cancellous bone. The rate of strength loss was commensurate with the predicted mechanical recovery of healing bone with analogous results in a composite that comprised also 25% (by weight) autograft. Mechanical testing in the long‐bone model demonstrated that PPF‐based bone‐graft substitute increased the flexural strength of K‐wire stabilized osteotomies. These results suggest that this type of bone graft substitute may have clinical utility in the stabilization of complex tubular bone fractures. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 311–317, 2003