Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population With High Consumption Levels
Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population With High Consumption Levels
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DOI：
10.1093/aje/kwv195
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发表时间：
2016-02-01
影响因子：
5
通讯作者：
Sunyer, Jordi
中科院分区：
文献类型：
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作者：
Julvez, Jordi;Mendez, Michelle;Sunyer, Jordi
怀孕期间食用海鲜被认为对儿童神经心理发育有益，但据我们所知，没有高脂肪鱼类消费的大型队列研究分析了海鲜亚型的相关性。我们在2004 - 2008年建立的基于人口的西班牙出生队列中，分别评估了1，892和1，589对14个月和5岁的母婴对。Bayley和McCarthy量表和儿童期神经心理发育测试被用于评估神经心理发育。多元线性回归模型的结果进行了调整的社会人口特征，并进一步调整脐带血汞或长链多不饱和脂肪酸浓度。总的来说，超过340克/周的建议限值的海鲜消费与神经心理学评分的10克/周增量相关。根据亚型，除了瘦肉鱼，食用大脂肪鱼显示出正相关;最高分位数（> 238 g/周）内的人的后代在麦卡锡一般认知评分中调整后增加了2.29分（95%置信区间：0.42，4.16）。在儿童发育不良综合征测试中也观察到了类似的结果。调整汞或长链多不饱和脂肪酸浓度后，β系数降低了15%-30%。在怀孕期间食用大脂肪鱼对儿童神经心理学有一定的好处，包括改善认知功能和保护自闭症谱系特征。
Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but to our knowledge no large cohort studies with high fatty fish consumption have analyzed the association by seafood subtype. We evaluated 1,892 and 1,589 mother-child pairs at the ages of 14 months and 5 years, respectively, in a population-based Spanish birth cohort established during 2004-2008. Bayley and McCarthy scales and the Childhood Asperger Syndrome Test were used to assess neuropsychological development. Results from multivariate linear regression models were adjusted for sociodemographic characteristics and further adjusted for umbilical cord blood mercury or long-chain polyunsaturated fatty acid concentrations. Overall, consumption of seafood above the recommended limit of 340 g/week was associated with 10-g/week increments in neuropsychological scores. By subtype, in addition to lean fish, consumption of large fatty fish showed a positive association; offspring of persons within the highest quantile (>238 g/week) had an adjusted increase of 2.29 points in McCarthy general cognitive score (95% confidence interval: 0.42, 4.16). Similar findings were observed for the Childhood Asperger Syndrome Test. Beta coefficients diminished 15%-30% after adjustment for mercury or long-chain polyunsaturated fatty acid concentrations. Consumption of large fatty fish during pregnancy presents moderate child neuropsychological benefits, including improvements in cognitive functioning and some protection from autism-spectrum traits.