EPSTEIN -BARR VIRUS ASSOCIATION WITH MALIGNANT LYMPHOMA SUBGROUPS IN ZARIA, NIGERIA.
EPSTEIN -BARR VIRUS ASSOCIATION WITH MALIGNANT LYMPHOMA SUBGROUPS IN ZARIA, NIGERIA.
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DOI：
10.4103/1116-5898.127096
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Shehu SM
中科院分区：
文献类型：
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作者：
Iliyasu Y;Ayers LW;Liman AA;Waziri GD;Shehu SM
据称，EB 病毒 (EBV) 感染了全球 90% 以上的人类，并呈终生潜伏感染状态。 EBV 是一种公认的致癌物质，与伯基特淋巴瘤 (BL)、浆母细胞淋巴瘤、弥漫性大细胞淋巴瘤 (DLBCL) 和霍奇金淋巴瘤 (HL) 的恶性淋巴瘤 (ML) 亚型有关。我们报告了部分患者群体中 EBV 与 ML 的关联。使用来自 ABUTH、Zaria 档案的石蜡块构建组织微阵列切片，使用 30 种针对常见非霍奇金淋巴瘤/霍奇金淋巴瘤抗原的单克隆抗体进行染色，并对 EBV 编码的 RNA 进行显色原位杂交 (CISH)。与非洲其他地区报道的相比，ML 与 EBV 的关联性要少。
Epstein-Barr virus (EBV) is said to infect more than 90% of humans worldwide with latent infection for life. A recognized carcinogen, EBV is linked to malignant lymphoma (ML) subtypes of Burkitt's lymphoma (BL), plasmablastic lymphoma, diffuse large cell lymphoma (DLBCL) and Hodgkin's lymphoma (HL). We report the association of EBV with ML in a segment of our patient population. Paraffin blocks from the archives of ABUTH, Zaria were used to construct tissue microarray sections stained using 30 monoclonal antibodies for common Non-Hodgkin's lymphoma/ Hodgkin's lymphoma antigen and chromogenic in situ hybridization (CISH) for EBV-encoded RNA were done. Fewer associations of ML with EBV were found than reported from elsewhere in Africa.