Hydroquinone-Assisted Synthesis of Branched Au-Ag Nanoparticles with Polydopamine Coating as Highly Efficient Photothermal Agents
Hydroquinone-Assisted Synthesis of Branched Au-Ag Nanoparticles with Polydopamine Coating as Highly Efficient Photothermal Agents
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对苯二酚辅助合成聚多巴胺涂层支化金银纳米粒子作为高效光热剂
DOI：
10.1021/acsami.5b02666
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发表时间：
2015-06-03
影响因子：
9.5
通讯作者：
Yang, Bai
中科院分区：
文献类型：
--
作者：
Li, Jing;Wang, Wenjing;Yang, Bai
尽管通过牺牲金属纳米粒子（NPs）种子与活性较低的金属离子之间的取代反应，电替换在制备具有多种形态的空心纳米结构方面取得了成功，但在制备支链合金纳米结构方面进展有限。本文报道了以对苯二酚（HQ）为还原剂制备富金核和银支链的支化Au-Ag NPs的扩展电替代方法。在HQ存在的情况下，预先形成的Ag种子被Au取代，反过来，提供Ag分支的生长。通过改变Ag种子、HAuCl4和HQ的投料比，可以调节NPs的大小和形态。因此，表面等离子体共振吸收被调谐到近红外（NIR）区域，使支链NPs成为光热治疗的潜在材料。支化后的NPs在室温下通过多巴胺聚合进一步包被聚多巴胺（PDA）外壳。与裸NPs相比，pda包覆的支链Au-Ag (Au-Ag@PDA) NPs表现出更好的稳定性、生物相容性和光热性能。体外实验表明，支链Au-Ag@PDA NPs是光热消融癌细胞的竞争剂。
Despite the success of galvanic replacement in preparing hollow nanostructures with diversified morphologies via the replacement reaction between sacrificial metal nanoparticles (NPs) seeds and less active metal ions, limited advances are made for producing branched alloy nanostructures. In this paper, we report an extended galvanic replacement for preparing branched Au-Ag NPs with Au-rich core and Ag branches using hydroquinone (HQ) as the reductant. In the presence of HQ the preformed Ag seeds are replaceable by Au and, in turn, supply the growth of Ag branches. By altering the feed ratio of Ag seeds, HAuCl4, and HQ the size and morphology of the NPs are tunable. Accordingly, the surface plasmon resonance absorption is tuned to near-infrared (NIR) region, making the branched NPs as potential materials in photothermal therapy. The branched NPs are further coated with polydopamine (PDA) shell via dopamine polymerization at room temperature. In comparison with bare NPs, PDA-coated branched Au-Ag (Au-Ag@PDA) NPs exhibit improved stability, biocompatibility, and photothermal performance. In vitro experiments indicate that the branched Au-Ag@PDA NPs are competitive agents for photothermal ablation of cancer cells.