Preparation and biological activity of N-sulfonated chondroitin and dermatan sulfate derivatives
Preparation and biological activity of N-sulfonated chondroitin and dermatan sulfate derivatives
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DOI：
10.1016/0008-6215(96)00129-2
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发表时间：
1996-08-26
影响因子：
3.1
通讯作者：
Linhardt, RJ
中科院分区：
文献类型：
--
作者：
Nadkarni, VD;Toida, T;Linhardt, RJ
硫酸软骨素和硫酸皮肤素是结构复杂的硫酸化线性多糖家族，称为糖胺聚糖（GAG），糖醛酸和N-乙酰化D-半乳糖胺残基交替[1]（方案1）。硫酸软骨素A（1A）由未硫酸化的D-葡萄糖醛酸1--* 3连接到N-乙酰化的4-硫酸化D-半乳糖胺，后者又通过1~ 4键连接到下一个D-葡萄糖醛酸残基。硫酸软骨素C（1B）在N-乙酰化的D-半乳糖胺上有一个6-硫酸酯基，取代了硫酸软骨素A中的4-硫酸酯基。硫酸皮肤素，也称为硫酸软骨素B（2），与硫酸软骨素A相似，但主要由L-艾杜糖醛酸组成，而不是D-葡萄糖醛酸。硫酸皮肤素和硫酸软骨素两者平均每个二糖单位含有一个硫酸基团。
Chondroitin and dermatan sulfates are families of structurally complex, sulfated, linear polysaccharides called glycosaminoglycans (GAGs) with alternating uronic acid and N-acetylated D-galactosamine residues [1](Scheme 1). Chondroitin sulfate A (1A) consists of unsulfated D-glucuronic acid 1--* 3 linked to N-acetylated, 4-sulfated D-galactosamine, which in turn is attached to the next D-glucuronic acid residue by a 1~ 4 linkage. Chondroitin sulfate C (1B) has a 6-sulfate group on the N-acetylated D-galactosamine in place of the 4-sulfate found in chondroitin sulfate A. Dermatan sulfate, also called chondroitin sulfate B (2), is similar to chondroitin sulfate A but instead of D-glucuronic acid it consists mainly of L-iduronic acid. Both dermatan and chondroitin sulfates contain, on the average, one sulfate group per disaccharide unit.