INTERFERON-GAMMA AND B-CELL STIMULATORY FACTOR-I RECIPROCALLY REGULATE IG ISOTYPE PRODUCTION
INTERFERON-GAMMA AND B-CELL STIMULATORY FACTOR-I RECIPROCALLY REGULATE IG ISOTYPE PRODUCTION
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DOI：
10.1126/science.3107127
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发表时间：
1987-05-22
期刊：
影响因子：
56.9
通讯作者：
PAUL, WE
中科院分区：
文献类型：
--
作者：
SNAPPER, CM;PAUL, WE
γ干扰素（IFN-γ）和B细胞刺激因子-1（BSF-1），也称为白细胞介素-4，是T细胞衍生的淋巴因子，对B细胞增殖和分化具有有效作用。它们通常由不同的T细胞克隆分泌。现在显示IFN-γ。刺激IgG 2a同种型的免疫球蛋白（IG）的表达并抑制IgG 3、IgG 1、IgG 2b和IgE的产生。相反，BSF-1在促进转换为IgG 1和IgE的表达方面具有强大的效果，但显著抑制IgM、IgG 3、IgG 2a和IgG 2b。这些结果表明，BSF-1和IFN-γ在细胞内表达。以及产生它们的T细胞可以在确定IG同种型应答中作为相互调节剂。IFN-γ的作用和BSF-1对同种型表达的影响是独立的。
Gamma interferon (IFN-.gamma.) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines that have potent effects on B cell proliferation and differentiation. They are often secreted by distinct T cell clones. It is now shown that IFN-.gamma. stimulates the expression of immunoglobulin (Ig) of the IgG2a isotype and inhibits the production of IgG3, IgG1, IgG2b, and IgE. By contrast, BSF-1 has powerful effects in promoting switching to the expression of IgG1 and IgE but markedly inhibits IgM, IgG3, IgG2a, and IgG2b. These results indicate that BSF-1 and IFN-.gamma. as well as the T cells that produce them may act as reciprocal regulatory agents in the determination of Ig isotype responses. The effects of IFN-.gamma. and BSF-1 on isotype expression are independent.