A Single Nucleotide Polymorphism in MicroRNA-146a Is Associated With the Risk for Nasopharyngeal Carcinoma
A Single Nucleotide Polymorphism in MicroRNA-146a Is Associated With the Risk for Nasopharyngeal Carcinoma
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microRNA-146a的单核苷酸多态性与鼻咽癌的风险相关
DOI：
10.1002/mc.21937
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发表时间：
2013-11-01
影响因子：
4.6
通讯作者：
To, Ka-Fai
中科院分区：
文献类型：
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作者：
Lung, Raymond Wai-Ming;Wang, Xingyan;To, Ka-Fai
miRNA-146 a前体区域（rs 2910164）内的常见GC多态性与各种癌症的风险相关，尽管潜在机制尚不清楚。本研究旨在探讨rs 2910164在鼻咽癌发病机制和易感性中的作用。采用熔解温度（Tm）-移位等位基因特异性分型方法，对233例鼻咽癌患者、173例正常对照和3613例健康老年人的GC基因多态性进行了研究。我们的病例对照研究结果表明CC基因型与鼻咽癌的危险效应相关（GC+GG vs. CC的校正比值比为0.49; 95%可信区间为0.35-0.69; P
A common GC polymorphism within miRNA-146a precursor region (rs2910164) has been associated with the risk of various cancers despite the underlying mechanism is unclear. In the current study, we aimed to examine the role of rs2910164 in the pathogenesis and predisposition to nasopharyngeal carcinoma (NPC). The GC polymorphism in 233 NPC patients, 173 matched controls and 3613 healthy elderly subjects in our locality were first determined using melting temperature (T-m)-shift allele-specific genotyping method. Results in our case-control study indicated that CC genotype was associated with the risk effect of NPC (adjusted odds ratio of GC+GG vs. CC, 0.49; 95% confidence interval, 0.35-0.69; P