COMPARISON BETWEEN THE PHARMACOLOGY OF DOPAMINE-RECEPTORS MEDIATING THE INHIBITION OF CELL FIRING IN RAT-BRAIN SLICES THROUGH THE SUBSTANTIA-NIGRA PARS COMPACTA AND VENTRAL TEGMENTAL AREA
COMPARISON BETWEEN THE PHARMACOLOGY OF DOPAMINE-RECEPTORS MEDIATING THE INHIBITION OF CELL FIRING IN RAT-BRAIN SLICES THROUGH THE SUBSTANTIA-NIGRA PARS COMPACTA AND VENTRAL TEGMENTAL AREA
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DOI：
10.1111/j.1476-5381.1994.tb13161.x
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发表时间：
1994-07-01
影响因子：
7.3
通讯作者：
SEABROOK, GR
中科院分区：
文献类型：
--
作者：
BOWERY, B;ROTHWELL, LA;SEABROOK, GR
1对大鼠脑片黑质腹侧被盖区和黑质腹侧被盖区的多巴胺能神经元进行电生理记录。比较了选择性多巴胺受体激动剂对高兴奋性神经元和抑制细胞放电的能力，以及多巴胺受体拮抗剂阻断对喹吡罗反应的能力。2检查了6种多巴胺受体激动剂对黑质内高兴奋性神经元的能力。其中，测试的最有效的配体是naxaglavine，ECH值为20 nM，估计最大值为10 mV。激动剂效力的顺序为纳沙佐米>喹吡罗>阿扑吗啡>多巴胺。3喹吡罗抑制黑质背侧部细胞放电的效力（pIC（50）= 7.65 +/- 0.06，n = 35）高于腹侧被盖区（pIC（50）= 7.24 +/- 0.06，n = 32; P
1 Electrophysiological recordings were made from presumed dopaminergic neurones in the substantia nigra pars compacta and ventral tegmental area of rat brain slices. The ability of selective dopamine receptor agonists to hyperpolarize neurones and inhibit cell firing, as well as the ability of dopamine receptor antagonists to block responses to quinpirole were compared.2 Six dopamine receptor agonists were examined for their ability to hyperpolarize neurones within the substantia nigra pars compacta. Of these, the most potent ligand tested was naxagolide with an ECH, value of 20 nM and estimated maximum of 10 mV. The rank order of agonist potency was naxagolide>quinpirole>apomorphine>dopamine.3 Quinpirole was more potent at inhibiting cell firing in the substantia nigra pars compacta (pIC(50) = 7.65 +/- 0.06, n = 35) than in the ventral tegmental area (pIC(50) = 7.24 +/- 0.06, n = 32; P