Receptor-binding function of type 1 pili effects bladder colonization by a clinical isolate of Escherichia coli.
Receptor-binding function of type 1 pili effects bladder colonization by a clinical isolate of Escherichia coli.
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1 型菌毛的受体结合功能影响临床分离的大肠杆菌在膀胱的定植。
DOI：
10.1128/iai.53.3.693-696.1986
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发表时间：
1986
影响因子：
3.1
通讯作者：
Orndorff,PE
中科院分区：
文献类型：
--
作者：
Keith,BR;Maurer,L;Spears,PA;Orndorff,PE
通过构建临床分离的大肠杆菌的两个突变株来检查1型皮利在促进膀胱定植中的作用。一个突变体是等基因的亲本菌株保存为菌毛受体结合所需的基因中的病变;另一个突变体是等基因的保存为菌毛结构亚基编码基因中的病变。使用混合感染的父母和突变株在上升的大鼠膀胱炎模型，我们发现，1型piliated突变体，缺乏受体结合功能是无效的膀胱定植突变体缺乏整个细胞器。
The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene encoding the pilus structural subunit. Using mixed infections of the parental and mutant strains in an ascending rat cystitis model, we found that type 1-piliated mutants that lacked the receptor-binding function were as ineffective in bladder colonization as were mutants lacking the entire organelle.