Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population
Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population
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DOI：
10.1016/j.jid.2018.08.028
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发表时间：
2019-03-01
影响因子：
6.5
通讯作者：
Ong, Peck Y.
中科院分区：
文献类型：
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作者：
Fuxench, Zelma C. Chiesa;Block, Julie K.;Ong, Peck Y.
基于人群的成人特应性皮炎患病率估计差异很大。本研究的目的是确定美国人群中特应性皮炎的患病率、疾病严重程度的分布及其对健康相关生活质量的影响。在1278名参与调查的成年人中，特应性皮炎的患病率（95%可信区间）为7.3%（5.9-8.8）。总体而言，60.1%（56.1-64.1）的参与者被归类为轻度疾病，28.9%（25.3-32.7）为中度疾病，11%为重度疾病（8.6-13.7）。特应性皮炎患者和病情较重的患者在皮肤科生活质量指数（AD患者的平均[标准差]= 4.71[6.44]，对照组= 0.97[2.12]）、医院焦虑（AD患者的平均[标准差]= 7.03[4.80]，对照组= 4.73[4.8]）和抑郁（AD患者的平均[标准差]= 5.83[4.54]，对照组= 3.62[3.61]）量表得分较高。表明对生活质量的影响更糟，焦虑或抑郁的可能性增加。根据我们的患病率估计，1650万成年人将被诊断为特应性皮炎，其中660万人符合中度至重度疾病的标准。我们的研究证实了这一人群中特应性皮炎的高患病率和疾病负担。
Population-based estimates on the prevalence of atopic dermatitis in adults vary widely. The objectives of this study were to determine the prevalence of atopic dermatitis in the population of the United States, the distribution of disease severity, and its impact on health-related quality of life. Among 1,278 participating adults, the prevalence (95% confidence interval) of atopic dermatitis was 7.3% (5.9-8.8). Overall, 60.1% (56.1-64.1) of participants were classified as having mild, 28.9% (25.3-32.7) as having moderate, and 11% as having severe (8.6-13.7) disease. Patients with atopic dermatitis and those with more severe disease had higher scores in the dermatology life quality index (mean [standard deviation] for AD patients = 4.71 [6.44] vs. control individuals = 0.97 [2.12]) (P < 0.001) and the hospital anxiety (mean [standard deviation] for AD patients = 7.03 [4.80] vs. control individuals = 4.73 [4.8]) and depression (mean, [standard deviation] for AD patients = 5.83 [4.54] vs. control individuals = 3.62 [3.61]) scales, indicating a worse impact on quality of life and an increased likelihood of anxiety or depression. Based on our prevalence estimates, 16.5 million adults would have a diagnosis of atopic dermatitis, with 6.6 million meeting criteria for moderate to severe disease. Our study confirms the high prevalence and disease burden of atopic dermatitis in this population.