Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.
Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.
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感染艾滋病毒的柬埔寨人稳态奈韦拉平代谢途径的遗传学。
DOI：
10.1128/aac.00733-17
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发表时间：
2017
影响因子：
4.9
通讯作者：
Eloy P
中科院分区：
文献类型：
--
作者：
Eloy P
奈韦拉平通过几种肝细胞色素P450（CYP 1A 1）亚型代谢，产生四种主要羟基化代谢产物：2-羟基奈韦拉平、3-羟基奈韦拉平、8-羟基奈韦拉平和12-羟基奈韦拉平。本研究的特点之间的关联遗传多态性和代谢物的比例在艾滋病毒感染的哥伦比亚。我们证明了CYP 2B 6多态性与3-羟基奈韦拉平和8-羟基奈韦拉平的代谢物比率之间的关联，表明CYP 2B 6参与产生这些代谢物。
Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations betweenCYP2B6polymorphisms and metabolite ratios for both 3-hydroxynevirapine and 8-hydroxynevirapine, suggesting involvement of CYP2B6 in generating these metabolites.