Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex
Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex
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DOI：
10.1086/314926
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发表时间：
1999-09-01
影响因子：
6.4
通讯作者：
Whitby, D
中科院分区：
文献类型：
--
作者：
Smith, NA;Sabin, CA;Whitby, D
流行病学研究将卡波西肉瘤与一种性传播病原体联系起来。人类疱疹病毒8型(HHV-8)很可能是这种病原体，但对传播途径的描述很差。为确定HHV-8是否通过性行为在异性之间传播，对2718名就诊性传播疾病(STD)门诊患者进行了HHV-8和单纯疱疹病毒2型(HSV-2)抗体检测，并对过去12个月的性伴和既往的性传播疾病进行了问卷调查。用Logistic回归分析可能的危险因素与HHV-8感染的关系。总体而言，HHV-8的血清阳性率为7.3%。在整个群体中，HHV-8的独立危险因素是家庭/双性恋和在非洲出生，在同性恋/双性恋男子中，梅毒和HSV-2病史以及人类免疫缺陷病毒血清阳性，在异性恋中没有证据表明有性传播；HHV-8血清阳性的唯一独立危险因素是在非洲出生。
Epidemiologic studies link Kaposi's sarcoma with a sexually transmitted agent. Human herpesvirus 8 (HHV-8) is likely to be that agent, but routes of transmission are poorly described. A seroepidemiologic study was conducted to determine whether HHV-8 is transmitted sexually between heterosexuals, Sera from 2718 patients attending a sexually transmitted disease (STD) clinic were tested for antibodies to HHV-8 and herpes simplex virus type 2 (HSV-2), Information on sex partners in the previous 12 months and past STDs were obtained by questionnaire. Relationships between possible risk factors and HHV-8 infection were assessed by logistic regression. Overall, seroprevalence of HHV-8 was 7.3%. Independent risk factors for HHV-8 in the whole group were home/bisexuality and birth in Africa and, among homo/ bisexual men, a history of syphilis and HSV-2 and human immunodeficiency virus seropositivity, Among heterosexuals there was no evidence for sexual transmission; the only independent risk factor for HHV-8 seropositivity was birth in Africa.