Histological hair removal study by ruby or alexandrite laser with comparative study on the effects of wavelength and fluence.
Histological hair removal study by ruby or alexandrite laser with comparative study on the effects of wavelength and fluence.
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DOI：
10.1080/14764170410029059
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发表时间：
2004-05-01
期刊：
影响因子：
--
通讯作者：
Kawana, Seiji
中科院分区：
文献类型：
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作者：
Kato, Tokue;Omi, Tokuya;Kawana, Seiji
背景：目前有几种不同的激光系统用于去除多余的毛发。在这项研究中，我们研究了毛囊的变化，脱毛后红宝石或翠绿宝石激光在不同的fluences.METHODS：不想要的头发进行了治疗红宝石激光（Chromos 694，ICN PhotonIcs，英国）在10，14或18 J/cm 2或与翠绿宝石激光（LPIR，Cynosure，美国）在11，14或17 J/cm 2。每次激光照射后立即和1个月后进行3 mm皮肤穿刺活检。标本染色进行组织学观察。应用免疫组化法和TUNEL法观察细胞增殖和凋亡情况。同样，电子显微镜观察examined.RESULTS：激光照射后，立即观察到中度卵泡损伤治疗后与任何类型的激光。一个月后，在用任一类型的激光治疗的皮肤中观察到毛囊囊状形成和异物巨细胞。一个类似的能量密度与任何激光治疗导致类似的组织学changes.CONCLUSION：在这项研究中，治疗后的组织学变化与红宝石或翠绿宝石激光在相同的能量密度是相似的。
BACKGROUND: Several different laser systems are currently used to remove unwanted hairs. In this study, we studied follicular changes following hair removal with ruby or alexandrite lasers at different fluences.METHODS: Unwanted hairs were treated with a ruby laser (Chromos 694, ICN PhotonIcs, UK) at 10, 14 or 18 J/cm2 or with an alexandrite laser (LPIR, Cynosure, USA) at 11, 14 or 17 J/cm2. A 3 mm skin punch biopsy was taken immediately after each laser exposure and also 1 month later. Specimens were stained for histological observation. They were observed using immunohistochemistry with antibodies recognizing factor VIII related antigen or PCNA, and also by the TUNEL method. Similarly, electron microscopic observation was examined.RESULTS: Immediately after the laser exposure, moderate follicular damage was observed following treatment with either type of laser. One month later, cystic formation of hair follicles and foreign body giant cells were observed in skin treated with either type of laser. A similar fluence with either laser treatment resulted in similar histological changes.CONCLUSION: In this study, the histological changes following treatment with a ruby or an alexandrite laser at the same fluence are similar.