The age at onset of rheumatoid arthritis is increasing in Japan: a nationwide database study
The age at onset of rheumatoid arthritis is increasing in Japan: a nationwide database study
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DOI：
10.1111/1756-185x.12998
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发表时间：
2017-07-01
影响因子：
2.5
通讯作者：
Tohma, Shigeto
中科院分区：
文献类型：
--
作者：
Kato, Eri;Sawada, Tetsuji;Tohma, Shigeto
目的通过全国性数据库确定日本类风湿关节炎（RA）发病年龄是否增加（日本iR-net的国家风湿性疾病数据库，NinJa）。方法我们分析了被诊断为早期RA的RA患者的数据（病程< 2年）和2003年、2008年或2013年新登记的RA患者人数。结果2002-2003年、2007-2008年、2013年新登记的RA患者人数2012-2013年分别为536、812和1 864。RA发病时的平均年龄从2002-2003年的55.8岁和2007-2008年的57.0岁显著增加至2012-2013年的59.9岁。高峰年龄从2002-2003年的50-59岁年龄组转移到2012-2013年的60-69岁年龄组。男性和女性RA患者的发病年龄无明显差异。值得注意的是，在2002-2003年期间，50-59岁年龄组（包括第一次婴儿潮）的类风湿关节炎患病率明显高于30-39岁和40-49岁年龄组，即使考虑到一般人群年龄构成的变化，结论我们已经证明，在日本RA发病的年龄已显着增加在过去的十年里。这可以归因于日本的人口老龄化。此外，第一次婴儿潮一代中RA的高患病率表明，环境因素也可能导致日本RA发病年龄的增加。
AimTo determine whether the age at onset of rheumatoid arthritis (RA) has increased in Japan using a nationwide database (National Database of Rheumatic Diseases by iR-net in Japan, NinJa).MethodWe analyzed the data of RA patients who had been diagnosed with early RA (disease duration < 2 years) and newly registered in 2003, 2008 or 2013.ResultsThe numbers of patients who developed RA in 2002-2003, 2007-2008, and 2012-2013 were 536, 812 and 1864, respectively. The mean age at RA onset increased significantly from 55.8 years in 2002-2003 and 57.0 years in 2007-2008 to 59.9 years in 2012-2013. The peak age shifted from the 50-59 years age group in 2002-2003 to the 60-69 years age group in 2012-2013. There was no apparent difference in the age at RA onset between male and female RA patients. Notably, in the period 2002-2003, the prevalence of RA was markedly higher in the age group of 50-59 years, which included the first baby boomers', than in the age groups of 30-39 and 40-49 years, even with consideration of the variations in the age composition of the general population.ConclusionsWe have demonstrated that the age at RA onset in Japan has increased significantly over the last decade. This can be attributed to Japan's aging population. In addition, the high prevalence of RA among the first baby boomers suggests that environmental factors might also have contributed to the increase in age at RA onset in Japan.