Bile Acids Activated Receptors Regulate Innate Immunity.
Bile Acids Activated Receptors Regulate Innate Immunity.
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胆汁酸激活受体调节先天免疫。
DOI：
10.3389/fimmu.2018.01853
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发表时间：
2018
影响因子：
7.3
通讯作者：
Distrutti E
中科院分区：
文献类型：
--
作者：
Fiorucci S;Biagioli M;Zampella A;Distrutti E
一旦专门知道它们在营养吸收中的作用，初级胆汁酸、鹅去氧胆酸和胆酸以及次级胆汁酸、脱氧胆酸和石胆酸是信号分子，通过宿主和肠道微生物群的相互作用由胆固醇分解产生，作用于几种受体，包括G蛋白偶联胆汁酸受体1（GPBAR 1或武田G蛋白受体5）和法尼醇-X-受体（FXR）。两种受体都位于宿主免疫系统与肠道微生物群的界面处，并且在先天免疫细胞如肠道和肝脏巨噬细胞、树突细胞和自然杀伤T细胞中高度表达。在这里，我们回顾GPBAR 1和FXR如何调节肠道和肝脏先天免疫系统，并有助于维持肠肝组织中的耐受性表型，以及如何调节先天免疫可能有助于解释GPBAR 1和FXR配体在免疫和代谢疾病中发挥的有益作用。
Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, acting on several receptors including the G protein-coupled bile acid receptor 1 (GPBAR1 or Takeda G-protein receptor 5) and the Farnesoid-X-Receptor (FXR). Both receptors are placed at the interface of the host immune system with the intestinal microbiota and are highly represented in cells of innate immunity such as intestinal and liver macrophages, dendritic cells and natural killer T cells. Here, we review how GPBAR1 and FXR modulate the intestinal and liver innate immune system and contribute to the maintenance of a tolerogenic phenotype in entero-hepatic tissues, and how regulation of innate immunity might help to explain beneficial effects exerted by GPBAR1 and FXR ligands in immune and metabolic disorders.
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影响因子：
4.6
作者：
Carino A;Cipriani S;Marchianò S;Biagioli M;Scarpelli P;Zampella A;Monti MC;Fiorucci S
通讯作者：
Fiorucci S
影响因子：
3.7
作者：
Cipriani S;Mencarelli A;Chini MG;Distrutti E;Renga B;Bifulco G;Baldelli F;Donini A;Fiorucci S
通讯作者：
Fiorucci S
影响因子：
4.6
作者：
Carino A;Cipriani S;Marchianò S;Biagioli M;Santorelli C;Donini A;Zampella A;Monti MC;Fiorucci S
通讯作者：
Fiorucci S
影响因子：
8
作者：
Cai, Shi-Ying;Ouyang, Xinshou;Boyer, James L.
通讯作者：
Boyer, James L.
DOI：
10.1152/ajpgi.00318.2003
发表时间：
2004-03-01
影响因子：
4.5
作者：
Gujral, JS;Liu, J;Jaeschke, H
通讯作者：
Jaeschke, H