DRAINAGE OF INTERSTITIAL FLUID FROM DIFFERENT REGIONS OF RAT-BRAIN
DRAINAGE OF INTERSTITIAL FLUID FROM DIFFERENT REGIONS OF RAT-BRAIN
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DOI：
10.1152/ajprenal.1984.246.6.f835
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
CSERR, HF
中科院分区：
文献类型：
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作者：
SZENTISTVANYI, I;PATLAK, CS;CSERR, HF
在麻醉大鼠上研究了不同脑区间质液（ISF）引流的动力学和途径。根据尾状核、内囊或中脑微量注射放射性碘化白蛋白（RISA）后从脑流出和流入CSF的速率估计脑引流和流入CSF的速率;根据注射入脑后辣根过氧化物酶和/或伊文思蓝标记白蛋白的分布追踪通过蛛网膜下腔和进入淋巴的流动途径。ISF排水速率（μ l·cm·dot.）g脑-1.cntdot. min-1）分别为0.18、0.19和0.29。从小脑延髓池采集的大量脑脊液中的ISF流量占中脑流出量的60-75%，但仅占尾状核或内囊流出量的10-15%。相对于散装CSF，RISA集中在蛛网膜下腔中，在脑周动脉周围的外膜组织袖中，可能是散装CSF中同位素回收率低的原因。从蛛网膜下腔，一些液体通过嗅神经鞘引流到咽后淋巴结。
Dynamics and pathways of interstitial fluid (ISF) drainage from different regions of brain were studied in anesthetized rats. Rates of drainage from brain and flow into CSF were estimated from the efflux from brain and influx into CSF of radioiodinated albumin (RISA) following microinjection into caudate nucleus, internal capsule or midbrain; pathways of flow through the subarachnoid space and into lymph were traced from the distribution of horseradish peroxidase and/or Evans blue-labeled albumin after injection into brain. ISF drainage rates (.mu.l .cntdot. g brain-1 .cntdot. min-1) estimated for the 3 injection sites were 0.18, 0.19 and 0.29, respectively. Flow of ISF into bulk CSF sampled from the cisterna magna accounted for 60-75% of efflux from midbrain but only 10-15% of efflux from caudate nucleus or internal capsule. RISA was concentrated in the subarachnoid space, relative to bulk CSF, in sleeves of adventitial tissue surrounding pericerebral arteries, possibly accounting for the low recovery of isotope from bulk CSF. From the subarachnoid space, some fluid drained via olfactory nerve sheaths to retropharyngeal lymph nodes.