Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.
Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.
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DOI：
10.1161/hyp.0000000000000033
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
American Heart Association Council on Hypertension
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文献类型：
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作者：
Townsend RR;Wilkinson IB;Schiffrin EL;Avolio AP;Chirinos JA;Cockcroft JR;Heffernan KS;Lakatta EG;McEniery CM;Mitchell GF;Najjar SS;Nichols WW;Urbina EM;Weber T;American Heart Association Council on Hypertension
汤森等人对动脉僵硬的血管研究699血压、血流量和动脉直径随每次心跳而变化。除了承重结构的被动力学特性外，动脉硬度还可以通过与细胞过程相关的功能成分来调节，在细胞过程中，血管壁硬度可以受到内皮功能的影响，通过调节平滑肌张力或改变细胞外基质的完整性。如本摘要所述，硬度是在不同类型的动脉(肌性的、弹性的)和横截面上、沿血管纵向或在两个方向上测量的。通常，动脉僵硬是通过脉搏波在特定节段(如主动脉)的传播速度来评估的。然而，通过对动脉僵硬的调查所解决的研究问题并不局限于这种用途，而且已经在大多数命名的人类大动脉中测量到了僵硬。2动脉硬度也是通过测量血管中的压力或直径，并将一个或几个现已广泛的公式应用于数据来得出反映所有动脉的这一固有属性的值来估计的。3.
Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and arterial diameter change with each heartbeat. In addition to the passive mechanical properties of the load-bearing structures, arterial stiffness can be modulated by functional components related to cellular processes in which wall stiffness can be affected by endothelial function through modulation of smooth muscle tone or by alterations in the integrity of the extracellular matrix. As developed in this summary statement, stiffness is measured in different kinds of arteries (muscular, elastic) and in cross section, longitudinally along the vessel, or in both directions. Often, arterial stiffness is assessed as the velocity of pulse-wave travel in a defined segment such as the aorta. However, the research questions addressed by investigations of arterial stiffness are not restricted to this use, and stiffness has been measured in most named large arteries in humans. 2 Arterial stiffness is also estimated by measuring pressure or diameter in a vessel and applying 1 or several of the now extensive formulas to the data to derive a value that reflects this inherent property of all arteries. 3