Environmental enrichment increases responding to contextual cues but decreases overall conditioned fear in the rat
Environmental enrichment increases responding to contextual cues but decreases overall conditioned fear in the rat
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DOI：
10.1016/j.bbr.2006.01.012
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发表时间：
2006-05-15
影响因子：
2.7
通讯作者：
Majchrzak, M
中科院分区：
文献类型：
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作者：
Barbelivien, A;Herbeaux, K;Majchrzak, M
本研究旨在探讨丰富环境对成年雌性大鼠语境加工各个方面的影响。在实验I中，简单的条件反射进行了研究，使用一个训练程序，允许遮蔽的上下文线索的信号footshock与离散的音调或训练程序，允许减少这种遮蔽明确unpairing的footshock和音调。实验二考察了语境辨别和语境选择设置。大鼠每天暴露于两种不同的环境中。在一种情况下，足电击后30秒的补偿赎罪，而在另一种情况下，相同的音调单独提出。实验3考察了对新情境的熟悉程度。实验1表明，丰富的环境减少了阴影的上下文线索的语气，也减少了冻结更预测的线索，根据所使用的训练程序。实验2表明，丰富的环境提高了大鼠区分两种环境的能力。实验3表明，丰富的大鼠比标准大鼠更快地熟悉新的环境。综上所述，这些结果表明，成年大鼠的环境丰富增强了对上下文线索的学习，并减少了与厌恶事件相关的整体恐惧。(C)2006 Elsevier B.V.保留所有权利。
This study aimed at investigating the effects of environmental enrichment on various aspects of contextual processing in adult female rats. In experiment I, simple conditioning was studied using either a training procedure allowing overshadowing of the contextual cues by signalling footshock with a discrete tone or a training procedure allowing a reduction of this overshadowing by explicitly unpairing the footshock and the tone. In experiment 2, contextual discrimination and contextual occasion-setting were assessed. Rats were daily exposed to two different contexts. In one context, a footshock was delivered 30 s after the offset of atone, whereas in the other context the same tone was presented alone. Experiment 3 examined familiarization to a new context. Experiment 1 showed that environmental enrichment reduced the overshadowing of contextual cues by the tone and also reduced freezing to the more predictive cue according to the training procedure used. Experiment 2 showed that environmental enrichment increased the ability of rats to discriminate two contexts. Experiment 3 showed that enriched rats familiarized faster to a new context than standard rats. Taken together, these results suggest that environmental enrichment in adult rats enhances learning about contextual cues and reduces overall fear associated with aversive events. (C) 2006 Elsevier B.V. All rights reserved.