Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T-1 Imaging
Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T-1 Imaging
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通过可激活 T1 成像实时监测三氧化二砷的释放和输送
DOI：
10.1021/nn506640h
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发表时间：
2015
期刊：
影响因子：
17.1
通讯作者：
Gao Jinhao
中科院分区：
文献类型：
--
作者：
Zhao Zhenghuan;Wang Xiaomin;Zhang Zongjun;Zhang Hui;Liu Hanyu;Zhu Xianglong;Li Hui;Chi Xiaoqin;Yin Zhenyu;Gao Jinhao
三氧化二砷（ATO）作为一种临床抗癌药物，其给药途径的研究已引起人们的广泛关注，以提高其药代动力学和生物利用度。实时和原位监测ATO在体内的行为对于有效的肿瘤治疗是非常必要的。在此，我们报告了一种基于ATO的多功能药物递送系统，该系统有效地递送ATO以治疗肿瘤，并允许通过可激活的T1成像实时监测ATO的释放。我们将水不溶性的亚砷酸锰络合物（ATO前药）负载到中空二氧化硅纳米颗粒中，形成pH敏感的多功能药物递送系统。酸性刺激触发锰离子和ATO的同时释放，这显著增加了T1信号（亮信号），并使ATO释放和递送的实时可视化和监测成为可能。此外，这种智能多功能药物递送系统显著提高了ATO功效，并强烈抑制了实体肿瘤的生长，而没有不良副作用。该策略对于癌症诊断和治疗中的治疗诊断药物递送的实时监测具有巨大潜力。
Delivery of arsenic trioxide (ATO), a clinical anticancer drug, has drawn much attention to improve its pharmacokinetics and bioavailability for efficient cancer therapy. Real-time andin situmonitoring of ATO behaviorsin vivois highly desirable for efficient tumor treatment. Herein, we report an ATO-based multifunctional drug delivery system that efficiently delivers ATO to treat tumors and allows real-time monitoring of ATO release by activatable T1imaging. We loaded water-insoluble manganese arsenite complexes, the ATO prodrug, into hollow silica nanoparticles to form a pH-sensitive multifunctional drug delivery system. Acidic stimuli triggered the simultaneous release of manganese ions and ATO, which dramatically increased the T1signal (bright signal) and enabled real-time visualization and monitoring of ATO release and delivery. Moreover, this smart multifunctional drug delivery system significantly improved ATO efficacy and strongly inhibited the growth of solid tumors without adverse side effects. This strategy has great potential for real-time monitoring of theranostic drug delivery in cancer diagnosis and therapy.