CONTROL OF CELL-DIVISION BY TENSION OR DIFFUSION
CONTROL OF CELL-DIVISION BY TENSION OR DIFFUSION
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DOI：
10.1038/274052a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
SEEHAR, GM
中科院分区：
文献类型：
--
作者：
CURTIS, ASG;SEEHAR, GM
有几类实验被解释为扩散边界层作用控制细胞分裂的证据，它们同样可以被解释为机械效应的作用。泵实验和创伤实验1都被解释为增加细胞和培养基之间代谢物交换速率刺激细胞周期，特别是G 0到S的转变的证据。然而，已经有许多观察证据表明，机械应力可能导致分裂增加2 -4。抽吸和创伤实验5可能会对细胞产生机械应力，因此现在是进行区分机械张力效应和改变扩散速率效应的实验的时候了。我们提供的实验证据表明，机械张力可能会刺激脊椎动物细胞的细胞周期。
SEVERAL types of experiment which have been interpreted as evidence for the control of cell division by the action of diffusion boundary layers can equally well be interpreted as being due to the action of mechanical effects. The pumping experiment, and wounding experiments1have all been interpreted as evidence that increasing the rate of exchange of metabolites between cell and medium stimulates the cell cycle and in particular the transition G0to S. However, there is already much observational evidence that suggests that mechanical stress may lead to increased division2–4. The pumping and wounding5experiments might mechanically stress cells so that it is timely to carry out an experiment which distinguishes between the effects of mechanical tension and the effects of changed diffusion rates. We provide experimental evidence that mechanical tension may stimulate the cell cycle in vertebrate cells.