Generic and disease-specific health related quality of life in non-cirrhotic, cirrhotic and transplanted liver patients: a cross-sectional study.
Generic and disease-specific health related quality of life in non-cirrhotic, cirrhotic and transplanted liver patients: a cross-sectional study.
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DOI：
10.1186/1471-230x-3-33
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发表时间：
2003-11-17
影响因子：
2.4
通讯作者：
Schalm SW
中科院分区：
文献类型：
--
作者：
van der Plas SM;Hansen BE;de Boer JB;Stijnen T;Passchier J;de Man RA;Schalm SW
在临床人群中进行慢性肝病患者健康相关生活质量（HRQoL）的研究。这些研究包括不同的疾病阶段，但病因学变化很小，没有移植患者。我们在病因多样的非肝病、肝病和移植肝患者中进行了一项大型HRQoL研究。我们比较了肝脏患者和健康对照之间的一般HRQoL和疲劳，并比较了非肝病、肝病和移植肝患者之间的疾病特异性和一般HRQoL和疲劳，并对病因进行了校正。荷兰肝病患者协会的成员接受了简表-36、肝病症状指数和多维疲劳指数-20。根据报告的临床特征，我们将应答者（n = 1175）分为非代偿性、代偿性、失代偿性或移植性。我们使用线性、有序和逻辑回归来比较组间的HRQoL。与健康对照组相比，所有肝脏患者的一般HRQoL和疲劳显着更差。失代偿性阿尔茨海默病患者的疾病特异性和一般HRQoL和疲劳比非阿尔茨海默病患者显着更差，而非阿尔茨海默病和代偿性阿尔茨海默病患者之间的HRQoL差异主要是微不足道的。移植患者表现出更好的一般HRQoL，更少的疲劳和更低的概率严重症状比非帕金森病患者，但几乎相同的概率症状障碍。慢性肝病患者的HRQoL取决于疾病分期和移植史。非失代偿性失代偿性失代偿患者的HRQoL相似。失代偿期患者的HRQoL最差，而移植患者的HRQoL明显优于缺血性和非缺血性患者。
Studies on Health Related Quality of Life (HRQoL) of chronic liver patients were performed in clinical populations. These studies included various disease stages but small variations in aetiology and no transplanted patients. We performed a large HRQoL study in non-cirrhotic, cirrhotic and transplanted liver patients with sufficient variety in aetiology. We compared the generic HRQoL and fatigue between liver patients and healthy controls and compared the disease-specific and generic HRQoL and fatigue between non-cirrhotic, cirrhotic and transplanted liver patients, corrected for aetiology. Members of the Dutch liver patient association received the Short Form-36, the Liver Disease Symptom Index and the Multidimensional Fatigue Index-20. Based on reported clinical characteristics we classified respondents (n = 1175) as non-cirrhotic, compensated cirrhotic, decompensated cirrhotic or transplants. We used linear, ordinal and logistic regression to compare the HRQoL between groups. All liver patients showed a significantly worse generic HRQoL and fatigue than healthy controls. Decompensated cirrhotic patients showed a significantly worse disease-specific and generic HRQoL and fatigue than non-cirrhotic patients, while HRQoL differences between non-cirrhotic and compensated cirrhotic patients were predominantly insignificant. Transplanted patients showed a better generic HRQoL, less fatigue and lower probabilities of severe symptoms than non-cirrhotic patients, but almost equal probabilities of symptom hindrance. HRQoL in chronic liver patients depends on disease stage and transplant history. Non-cirrhotic and compensated cirrhotic patients have a similar HRQoL. Decompensated patients show the worst HRQoL, while transplanted patients show a significantly better HRQoL than cirrhotic and non-cirrhotic patients.