Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer?
Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer?
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DOI：
10.1002/ddr.21276
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发表时间：
2015-11-01
影响因子：
3.8
通讯作者：
Comer, Brian S.
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文献类型：
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作者：
Comer, Brian S.
MicroRNA（miR）-155和环氧合酶（考克斯）-2在包括结直肠癌在内的许多癌症中均升高。miR-155增强考克斯-2表达，并且是上皮-间充质转化和炎症的既定调节剂。抑制miR-155或考克斯-2对致瘤性表现出类似的负面影响。因此，假设miR-155可能是拮抗结肠直肠癌和其他癌症中考克斯-2表达的有希望的靶标。药物开发研究76：354-356，2015年。(c)2015 Wiley Periodicals，Inc.
MicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammation. Inhibition of miR-155 or COX-2 exhibit similar negative effects on tumorigenicity. Thus, it is hypothesized that miR-155 may be a promising target for antagonizing COX-2 expression in colorectal and other cancers. Drug Dev Res 76 : 354-356, 2015. (c) 2015 Wiley Periodicals, Inc.