Acupuncture modulates resting state connectivity in default and sensorimotor brain networks
Acupuncture modulates resting state connectivity in default and sensorimotor brain networks
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DOI：
10.1016/j.pain.2008.01.011
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发表时间：
2008-06-15
期刊：
影响因子：
7.4
通讯作者：
Napadow, Vitaly
中科院分区：
文献类型：
--
作者：
Dhond, Rupali P.;Yeh, Calvin;Napadow, Vitaly
先前的研究已经在静息fMRI数据中定义了低频、空间一致的网络，这可能反映了功能连接。我们试图探索一个复杂的体感刺激，针灸，如何影响两个网络的内在连通性：默认模式网络（DMN）和感觉运动网络（SMN）。我们分析静息fMRI数据在verum和假针刺前后。通过测量心率变异性（HRV），使用心电图数据推断自主调节。采用概率独立分量分析将静息fMRI数据分离为DMN和SMN分量。在verum（而不是sham）之后，针灸增加了DMN与疼痛（前扣带皮层（ACC），导水管周围灰质），情感（杏仁核，ACC）和记忆（海马形成，中颞回）相关的大脑区域的连接。此外，DMN与海马（一个已知支持记忆并与自主脑区域相互连接的区域）形成的连接增加与针灸诱导的交感相关HRV指标（LFu）的增加呈负相关，与副交感相关指标（HFu）呈正相关。在verum（而不是sham）之后，针灸也增加了与疼痛相关的大脑区域（ACC，小脑）的SMN连通性。我们将真骨针刺与假针刺之间的差异归因于真骨针刺所引起的更多样、更强烈的感觉。我们的研究结果首次表明，针灸可以增强静息脑网络的空间范围，包括抗伤害、记忆和情感脑区域。这种调节和交感迷走神经反应可能与针刺镇痛和其他潜在的治疗效果有关。(C) 2008年国际疼痛研究协会。Elsevier B.V.版权所有。
Previous studies have defined low-frequency, spatially consistent networks in resting fMRI data which may reflect functional connectivity. We sought to explore how a complex somatosensory stimulation, acupuncture, influences intrinsic connectivity in two of these networks: the default mode network (DMN) and sensorimotor network (SMN). We analyzed resting fMRI data taken before and after verum and sham acupuncture. Electrocardiography data were used to infer autonomic modulation through measures of heart rate variability (HRV). Probabilistic independent component analysis was used to separate resting fMRI data into DMN and SMN components. Following verum, but not sham, acupuncture there was increased DMN connectivity with pain (anterior cingulate cortex (ACC), periaqueductal gray), affective (amygdala, ACC), and memory (hippocampal formation, middle temporal gyrus) related brain regions. Furthermore, increased DMN connectivity with the hippocampal formation, a region known to support memory and interconnected with autonomic brain regions, was negatively correlated with acupuncture-induced increase in a sympathetic related HRV metric (LFu), and positively correlated with a parasympathetic related metric (HFu). Following verum, but not sham, acupuncture there was also increased SMN connectivity with pain-related brain regions (ACC, cerebellum). We attribute differences between verum and sham acupuncture to more varied and stronger sensations evoked by verum acupuncture. Our results demonstrate for the first time that acupuncture can enhance the post-stimulation spatial extent of resting brain networks to include anti-nociceptive, memory, and affective brain regions. This modulation and sympathovagal response may relate to acupuncture analgesia and other potential therapeutic effects. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.