NREM sleep in the rodent neocortex and hippocampus reflects excitable dynamics
NREM sleep in the rodent neocortex and hippocampus reflects excitable dynamics
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DOI：
10.1038/s41467-019-10327-5
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发表时间：
2019-06-06
影响因子：
16.6
通讯作者：
Rinzel, John
中科院分区：
文献类型：
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作者：
Levenstein, Daniel;Buzsaki, Gyorgy;Rinzel, John
在非快速眼动 (NREM) 睡眠期间，哺乳动物前脑中的神经元群在尖峰期和不活动期之间交替。这些交替被称为新皮质中的缓慢振荡和海马体中的尖锐波波纹，通常被单独考虑，但对于 NREM 功能都至关重要。通过直接比较自然睡眠大鼠的实验观察与适应的循环神经元群的平均场模型，我们发现新皮质交替反映了一种动态机制，其中稳定的活动状态被短暂的非活动状态（慢波）打断，而海马交替反映了稳定的非活动状态被短暂的活动状态（尖波）打断。我们认为，在啮齿动物的 NREM 睡眠期间，海马和新皮质群体是兴奋的：每个都处于稳定状态，内部波动或外部扰动可以唤起介导 NREM 功能的刻板群体事件。
During non-rapid eye movement (NREM) sleep, neuronal populations in the mammalian forebrain alternate between periods of spiking and inactivity. Termed the slow oscillation in the neocortex and sharp wave-ripples in the hippocampus, these alternations are often considered separately but are both crucial for NREM functions. By directly comparing experimental observations of naturally-sleeping rats with a mean field model of an adapting, recurrent neuronal population, we find that the neocortical alternations reflect a dynamical regime in which a stable active state is interrupted by transient inactive states (slow waves) while the hippocampal alternations reflect a stable inactive state interrupted by transient active states (sharp waves). We propose that during NREM sleep in the rodent, hippocampal and neocortical populations are excitable: each in a stable state from which internal fluctuations or external perturbation can evoke the stereotyped population events that mediate NREM functions.