Functions of miRNAs during Mammalian Heart Development.
Functions of miRNAs during Mammalian Heart Development.
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DOI：
10.3390/ijms17050789
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发表时间：
2016-05-21
影响因子：
5.6
通讯作者：
Jiao K
中科院分区：
文献类型：
--
作者：
Yan S;Jiao K
MicroRNAs(MiRNAs)在哺乳动物心脏发育过程中发挥着重要作用，已成为心血管疾病的治疗靶点。哺乳动物胚胎心脏在发育过程中主要来源于四种主要细胞类型。这些细胞包括心肌细胞、心内膜细胞、心外膜细胞和神经脊细胞。最近的数据发现，各种miRNAs是这些细胞类型正确分化、增殖和生存的关键调节因子。在这篇综述中，我们简要介绍了对哺乳动物心脏发育的当代理解。我们还重点介绍了心脏miRNAs领域的最新进展及其在不同细胞类型发育过程中的功能。
MicroRNAs (miRNAs) play essential roles during mammalian heart development and have emerged as attractive therapeutic targets for cardiovascular diseases. The mammalian embryonic heart is mainly derived from four major cell types during development. These include cardiomyocytes, endocardial cells, epicardial cells, and neural crest cells. Recent data have identified various miRNAs as critical regulators of the proper differentiation, proliferation, and survival of these cell types. In this review, we briefly introduce the contemporary understanding of mammalian cardiac development. We also focus on recent developments in the field of cardiac miRNAs and their functions during the development of different cell types.