Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome
Thalidomide in the Treatment of Sweet's Syndrome and Eosinophilic Folliculitis Associated With Immune Reconstitution Inflammatory Syndrome
复制标题
沙利度胺治疗斯威特综合征和与免疫重建炎症综合征相关的嗜酸性毛囊炎
DOI：
10.3389/fmed.2019.00343
复制
发表时间：
2020-01-21
影响因子：
3.9
通讯作者：
Li, Yu-Ye
中科院分区：
文献类型：
--
作者：
Dong, Rong-Jing;Huang, Shi-Zhen;Li, Yu-Ye
Sweet综合征和嗜酸性毛囊炎均为无菌性炎性皮炎，主要原因分别为中性粒细胞和嗜酸性粒细胞浸润皮肤。这些疾病很少在同一患者中重叠或共存，特别是在HIV感染者中共存。在这里，我们报告了一个罕见的情况下，艾滋病患者谁开发嗜酸性毛囊炎和Sweet综合征在1个月内的初始抗逆转录病毒治疗，可能是由于免疫重建炎症综合征。CD 4 + T细胞计数在1个月内从70个/μL急剧增加到249个/μL。有趣的是，病人是迅速和惊人的反应沙利度胺，它具有抗炎，免疫调节，抑制中性粒细胞趋化性等，此外，我们集中我们的注意力在讨论的临床，病理学和可能的致病方面的罕见重叠的艾滋病毒并发嗜酸性粒细胞和嗜酸性粒细胞皮肤病。
Sweet's syndrome and eosinophilic folliculitis are aseptic inflammatory dermatitis mainly because of infiltrated neutrophils and eosinophils on skin, respectively. These diseases rarely overlap or coexist in the same patient, especially co-occur in HIV infected patient. Here, we report a rare case of an AIDS patient who developed eosinophilic folliculitis and Sweet's syndrome within 1 month of initial antiretroviral therapy, presumably due to immune reconstitution inflammatory syndrome. The CD4+ T cell counts increased dramatically from 70 to 249 cells/μL within a period of 1 month. Interestingly, the patient was rapidly and strikingly responsive to thalidomide, which has anti-inflammatory, immune regulation, inhibition of neutrophil chemotaxis etc. Moreover, we focused our attention on discussing the clinical, pathological, and possible pathogenic aspects of the rare overlap of HIV complicated with neutrophilic and eosinophilic dermatosis.