SOBOLHDMR: A General-Purpose Modeling Software
SOBOLHDMR: A General-Purpose Modeling Software
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DOI：
10.1007/978-1-62703-625-2_16
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发表时间：
2013-01-01
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通讯作者：
Kucherenko, Sergei
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文献类型：
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作者：
Kucherenko, Sergei
合成生物学的主要方法之一是开发和实现产生可再现和可控系统行为的最小电路。然而，大多数生物系统是高度复杂的，可持续的最小电路的设计可能具有挑战性。SobolHDMR是一个通用的元建模软件，可用于降低数学模型的复杂性，例如代谢网络和其他生物途径的数学模型，产生更简单的描述，保留原始模型的特征。这些描述可以作为设计最小电路或人工网络的基础。
One of the dominant approaches in synthetic biology is the development and implementation of minimal circuits that generate reproducible and controllable system behavior. However, most biological systems are highly complicated and the design of sustainable minimal circuits can be challenging. SobolHDMR is a general-purpose metamodeling software that can be used to reduce the complexity of mathematical models, such as those for metabolic networks and other biological pathways, yielding simpler descriptions that retain the features of the original model. These descriptions can be used as the basis for the design of minimal circuits or artificial networks.