TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis
TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis
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TNIP1/ANXA6 和 CSMD1 变异与吸烟、饮酒相互作用影响银屑病风险
DOI：
10.1016/j.jdermsci.2013.02.006
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发表时间：
2013-05-01
影响因子：
4.6
通讯作者：
Zhang, Xue-jun
中科院分区：
文献类型：
--
作者：
Yin, Xian-yong;Cheng, Hui;Zhang, Xue-jun
背景资料：银屑病是一种常见的多因素皮肤病，基因-基因和基因-环境相互作用可影响银屑病的发病、临床表现和病程，目的：探讨银屑病易感基因与吸烟、饮酒之间的基因-环境相互作用。采用两阶段病例对照设计，我们分别用ERAP 1、PTTG 1、CSMD 1、TTG 1上的9个单核苷酸多态性（SNP）寻找吸烟和饮酒之间的成对相互作用。GJB 2、SERPINB 8、ZNF 816 A和TNIP 1/ANXA 6与7，223例受试者的银屑病风险相关。结果：rs3762999与饮酒有显著的交互作用（p = 0.0257）和rs 999556 TNIP/ANXA 6时（p = 0.0071）; rs7007032时吸烟（p = 0.0023）和rs 10088247（p = 0.0023）。结论：本研究为TNIP 1/ANXA 6与饮酒、CSMDI和吸烟之间的基因-环境相互作用提供了经验证据，强调了基因-环境相互作用在银屑病发病机制中的重要性。(C)2013年日本皮肤病研究学会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Background: Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course.Objective: To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol intake.Methods: Using a two-stage case-control design, we searched for pairwise interactions between cigarette smoking and alcohol intake respectively with 9 single nucleotide polymorphisms (SNPs) at ERAP1, PTTG1, CSMD1, GJB2, SERPINB8, ZNF816A and TNIP1/ANXA6 that have been associated with risk for psoriasis in 7,223 subjects. Multiple logistic regression analysis was used for data analysis.Results: Significant interactions were found for alcohol intake with rs3762999 (p = 0.0257) and rs999556 (p = 0.0071) at TNIP/ANXA6; and for cigarette smoking with rs7007032 (p = 0.0023) and rs 10088247 (p = 0.0023) at CSMD1.Conclusion: This study provides empirical evidence for the gene-environment interactions between TNIP1/ANXA6 and alcohol use, CSMDI and cigarette smoking, highlighting the importance of gene-environment interactions in the pathogenesis of psoriasis. (C) 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.