The Effect of Paternal Age on Fetal Birth Outcomes
The Effect of Paternal Age on Fetal Birth Outcomes
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DOI：
10.1177/1557988312440718
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发表时间：
2012-09-01
影响因子：
2.3
通讯作者：
Mbah, Alfred K.
中科院分区：
文献类型：
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作者：
Alio, Amina P.;Salihu, Hamisu M.;Mbah, Alfred K.
调查父亲年龄在不良生育结果中的作用的研究有限。这项基于人群的回溯性队列研究使用了1989年至2005年密苏里州母亲相关的数据集，以评估父亲的年龄是否影响胎儿出生结果：低出生体重(LBW)、早产(PTB)、死产和小于胎龄(SGA)。我们使用广义估计方程框架检查了七个父亲年龄组(45岁)的婴儿的这些结果。与父亲年龄较小(25-29岁)的婴儿相比，父亲年龄在40-45岁之间的婴儿死产风险增加24%，但发生SGA的风险降低。观察到，父亲年龄较大(45岁)的婴儿晚期死产的风险增加了48%。此外，观察到父亲年龄较高(45岁)导致LBW、PTB和VPTB(早产)婴儿的风险分别增加19%、13%和29%。父亲年龄在30岁到39岁之间的婴儿患LBW、PTB和SGA的风险较低，而父亲年龄在24岁或以下的婴儿经历这些不良后果的可能性较高。这些发现表明，父亲的年龄影响出生结果，值得进一步研究。
Research investigating the role of paternal age in adverse birth outcomes is limited. This population-based retrospective cohort study used the Missouri maternally linked data set from 1989 to 2005 to assess whether paternal age affects fetal birth outcomes: low birth weight (LBW), preterm birth (PTB), stillbirth, and small size for gestational age (SGA). We examined these outcomes among infants across seven paternal age-groups (45 years) using the generalized estimating equation framework. Compared with infants born to younger fathers (25-29 years), infants born to fathers aged 40 to 45 years had a 24% increased risk of stillbirth but a reduced risk of SGA. A 48% increased risk of late stillbirth was observed in infants born to advanced paternal age (>45 years). Moreover, advanced paternal age (>45 years) was observed to result in a 19%, 13%, and 29% greater risk for LBW, PTB, and VPTB (very preterm birth) infants, respectively. Infants born to fathers aged 30 to 39 years had a lower risk of LBW, PTB, and SGA, whereas those born to fathers aged 24 years or younger had an elevated likelihood of experiencing these same adverse outcomes. These findings demonstrate that paternal age influences birth outcomes and warrants further investigation.