Glucose measurement in patients with diabetes mellitus with dermal interstitial fluid
Glucose measurement in patients with diabetes mellitus with dermal interstitial fluid
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DOI：
10.1016/s0022-2143(97)90044-5
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发表时间：
1997-10-01
期刊：
影响因子：
--
通讯作者：
Thomas, W
中科院分区：
文献类型：
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作者：
Bantle, JP;Thomas, W
虽然测量毛细血管血糖仍然是糖尿病患者自我监测的标准方法，但一种侵入性较小的监测方法是可取的。测量真皮间质液葡萄糖可能满足这一需要。为了验证这种可能性，我们在17例1型糖尿病患者餐前和餐后5小时血糖变化迅速的时间段内测量了血糖、毛细血管血糖（现行标准）和真皮间质液葡萄糖。目的是评估真皮间质液葡萄糖在广泛的潜在葡萄糖浓度范围内准确预测血浆葡萄糖的能力。真皮间质液葡萄糖与血浆葡萄糖高度相关（r = 0.95, p < 0.0001）。真皮间质液葡萄糖和血浆葡萄糖的平均绝对和百分比差异分别为1.2 mmol/L （21 mg/dl）和10.6%。真皮间质液葡萄糖和血浆葡萄糖的动力学相似。真皮间质液葡萄糖和血浆葡萄糖在平均葡萄糖偏移、葡萄糖峰值浓度或到达葡萄糖峰值浓度的时间上无显著差异。真皮间质液葡萄糖与血浆葡萄糖的相关性与毛细血管血糖与血浆葡萄糖的相关性一样强。由此可见，真皮间质液葡萄糖可用于估测血糖水平，具有监测糖尿病患者血糖水平的潜力。
Although measurement of capillary blood glucose remains the standard method of self-monitoring for persons with diabetes mellitus, a less-invasive method of monitoring would be desirable. Measurement of dermal interstitial fluid glucose might meet this need. To test this possibility, plasma glucose, capillary blood glucose (current standard), and dermal Interstitial fluid glucose were measured in 17 subjects with type I diabetes during a 5-hour pre- and postprandial period when plasma glucose was changing rapidly. The objective was to assess the ability of dermal interstitial fluid glucose to accurately predict plasma glucose over a wide range of potential glucose concentrations. Dermal interstitial fluid glucose was highly correlated with plasma glucose (r = 0.95, p < 0.0001). The mean absolute and percent differences between dermal interstitial fluid glucose and plasma glucose were 1.2 mmol/L (21 mg/dl) and 10.6%, respectively. The kinetics of dermal interstitial fluid glucose and plasma glucose were similar. There was no significant difference between dermal interstitial fluid glucose and plasma glucose in mean glucose excursion, peak glucose concentration, or time to peak glucose concentration. The correlation between dermal interstitial fluid glucose and plasma glucose was as strong as the correlation between capillary blood glucose and plasma glucose. In conclusion, dermal interstitial fluid glucose can be used to estimate plasma glucose, and has the potential to be used for monitoring patients with diabetes mellitus.