Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases
Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases
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蒙古沙鼠的幽门螺杆菌感染不会引发血液系统疾病
DOI：
10.3748/wjg.v20.i34.12308
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发表时间：
2014-09-14
影响因子：
4.3
通讯作者：
Lu, Nong-Hua
中科院分区：
文献类型：
--
作者：
Xie, Chuan;Xu, Li-Yao;Lu, Nong-Hua
目的：探讨幽门螺杆菌(Hp)感染在沙土鼠特发性血小板减少性紫癜(ITP)或缺铁性贫血(IDA)发病中的作用。两组受试者的饮食和食物量都相同。然后将每组动物分为3个亚组，分别在6、12、18mo处死动物进行分析。结果：两组患者的血小板计数(938.00+/-270.27/L vs 962.95+/-162.56×10(9)/L)、红细胞计数(8.11+/-1.25/L vs 8.44+/-1.48×10(12)/L)、对照组和Hp感染组在18mo时的Hb水平分别为136.9+/-8.76g/L和123.21+/-18.42g/L。除平均红细胞体积(MCV)外，其余各项指标，包括白细胞计数、红细胞压积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度、红细胞分布宽度、平均血小板体积、血小板分布宽度、淋巴细胞计数和淋巴细胞计数百分比，在各个时间点与对照组相比均无显著差异。18mo时幽门螺杆菌感染组红细胞平均体积(52.32f/L+/-2.86f/L)显著低于对照组(55.63+/-1.89f/L)(P=0.005)。6个月(54.40±2.44 f/L vs 53.30±1.86 f/L)和12个月(53.73±2.31 f/L vs 54.80+/-3.34 f/L)差异无统计学意义。(C)2014百仕登出版集团有限公司，版权所有。
AIM: To investigate whether Helicobacter pylori (H. pylori) infection contributes to idiopathic thrombocytopenic purpura (ITP) or iron-deficiency anemia (IDA) onset in gerbils.METHODS: A total of 135 Mongolian gerbils were randomly divided into two groups: an H. pylori infection group and a control group. Both groups were fed the same diet and the same amount of food. Each group was then divided into three subgroups, which were sacrificed at 6, 12, or 18 mo for analysis. At each time point, arterial blood was collected from the abdominal aorta and a complete blood cell count was analyzed in the clinical laboratory in the First Affiliated Hospital of Nanchang University.RESULTS: There were no significant differences in platelet counts (938.00 +/- 270.27/L vs 962.95 +/- 162.56 x 10(9)/L), red blood cell counts (8.11 +/- 1.25/L vs 8.44 +/- 1.48 x 10(12)/L), or hemoglobin levels (136.9 +/- 8.76 g/L vs 123.21 +/- 18.42 g/L) between the control and the H. pylori groups, respectively, at 18 mo. With the exception of the mean corpuscular volume (MCV), all other indicators, including white blood cell counts, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, mean platelet volume, platelet distribution width, lymphocyte count, and lymphocyte count percentage, showed no significant differences between the control and H. pylori infection groups at each time point. The MCV in the H. pylori infection group (52.32 f/L +/- 2.86 f/L) was significantly lower than the control group (55.63 +/- 1.89 f/L) at 18 mo (P = 0.005), though no significant differences were observed at 6 (54.40 +/- 2.44 f/L vs 53.30 +/- 1.86 f/L) or 12 mo (53.73 +/- 2.31 f/L vs 54.80 +/- 3.34 f/L).CONCLUSION: A single H. pylori infection is insufficient to cause onset of ITP or IDA and other factors may be required for disease onset. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.