Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure
Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure
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DOI：
10.1139/cjpp-2012-0341
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发表时间：
2013-10-01
影响因子：
2.1
通讯作者：
Hernandez-Saavedra, Daniel
中科院分区：
文献类型：
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作者：
Diaz-Flores, Margarita;Cruz, Miguel;Hernandez-Saavedra, Daniel
来自腹部脂肪和不受控制的葡萄糖代谢的活性氧是氧化应激和代谢综合征 (MetS) 发展的促成因素。本研究旨在评估每日口服甘氨酸补充剂对 MetS 患者抗氧化酶和脂质过氧化的影响。该研究包括 60 名志愿者：其中 30 名受试者补充甘氨酸（15 克/天），30 名受试者服用安慰剂 3 个月。我们分析了血浆中的硫代巴比妥酸反应物质（TBARS）和S-亚硝基血红蛋白（SNO-Hb）；红细胞中葡萄糖-6-磷酸脱氢酶 (G6PD)、超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT) 和谷胱甘肽过氧化物酶 (GPX) 的酶活性；以及白细胞中 CAT、GPX 和 SOD2 的表达。与安慰剂治疗组相比，接受甘氨酸治疗的个体 TBARS 降低了 25%。此外，甘氨酸处理组的 SOD 特异性活性降低了 20%，这与 SOD2 表达相关。甘氨酸处理的男性组中 G6PD 活性和 SNO-Hb 水平增加。接受甘氨酸治疗的男性的收缩压 (SBP) 也显着降低 (p = 0.043)。甘氨酸在平衡人体内氧化还原反应方面发挥着重要作用，从而保护 MetS 患者免受氧化损伤。
Reactive oxygen species derived from abdominal fat and uncontrolled glucose metabolism are contributing factors to both oxidative stress and the development of metabolic syndrome (MetS). This study was designed to evaluate the effects of daily administration of an oral glycine supplement on antioxidant enzymes and lipid peroxidation in MetS patients. The study included 60 volunteers: 30 individuals that were supplemented with glycine (15 g/day) and 30 that were given a placebo for 3 months. We analysed thiobarbituric acid reactive substances (TBARS) and S-nitrosohemoglobin (SNO-Hb) in plasma; the enzymatic activities of glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in erythrocytes; and the expression of CAT, GPX, and SOD2 in leukocytes. Individuals treated with glycine showed a 25% decrease in TBARS compared with the placebo-treated group. Furthermore, there was a 20% reduction in SOD-specific activity in the glycine-treated group, which correlated with SOD2 expression. G6PD activity and SNO-Hb levels increased in the glycine-treated male group. Systolic blood pressure (SBP) also showed a significant decrease in the glycine-treated men (p = 0.043). Glycine plays an important role in balancing the redox reactions in the human body, thus protecting against oxidative damage in MetS patients.