ASSOCIATION OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTION AND AUTOIMMUNE PHENOMENA
ASSOCIATION OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTION AND AUTOIMMUNE PHENOMENA
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DOI：
10.1016/0002-9343(88)90012-5
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发表时间：
1988-01-01
影响因子：
5.9
通讯作者：
ZOLLAPAZNER, S
中科院分区：
文献类型：
--
作者：
KOPELMAN, RG;ZOLLAPAZNER, S
感染人类免疫缺陷病毒的患者有各种表现，包括发烧、淋巴结病、皮疹、肾功能障碍以及神经和血液系统疾病。其中许多特征也见于系统性红斑狼疮(SLE)患者。本文描述了5例最终诊断为获得性免疫缺陷综合征(AIDS)或艾滋病相关复合体(ARC)的患者，其中鉴别诊断包括SLE，原因是多系统疾病和自身免疫现象，尤其是抗核抗体阳性。对151例艾滋病或ARC患者的血清标本进行检测，发现19例低滴度抗核抗体阳性(17例为1：20，2例为1：160)。这些观察表明，SLE和人类免疫缺陷病毒感染可能具有共同的临床和血清学特征。
Patients infected with human immunodeficiency virus have a variety of presentations including fevers, lymphadenopathy, rash, renal dysfunction, and neurologic and hematologic disorders. Many of these features are also seen in patients with systemic lupus erythematous (SLE). Herein are described five patients ultimately diagnosed as having acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) in whom the differential diagnosis included SLE because of multi-system disease and autoimmune phenomena, especially positive antinuclear antibodies. Serum samples from 151 consecutive patients with AIDS or ARC were examined and 19 with low titer-positive antinuclear antibodies were found (17 at 1:20 and two at 1:160). These observations suggest that SLE and human immunodeficiency virus infection may share clinical and serologic features.