Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration
Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration
复制标题
DOI：
10.1073/pnas.0810650105
复制
发表时间：
2008-12-09
影响因子：
11.1
通讯作者：
Cammarota, Martin
中科院分区：
文献类型：
--
作者：
Izquierdo, Ivan;Bevilaqua, Lia R.;Cammarota, Martin
年龄在16-82岁、受过至少10年教育的健康人类志愿者接受了两种不同的记忆任务。第一项任务涉及附带记忆。受试者被尽可能随意地问道：“你两天前在电视上看过电影吗？”那7天前呢？如果是这样的话，你还记得这部电影的片名(S)和前两位演员的名字吗？在所有年龄组(16-20岁、21-30岁、31-40岁、41-60岁和61-82岁)的第二天分数中，保留分数(最高=3分：标题、演员1和演员2)同样高(总体平均值=2.6，n=61)。在三个年龄较大的组中，7天前看过的电影的分数随着年龄的增加而显著递减，这表明这种类型的记忆从41-50岁开始下降，并随着时间的推移变得更加广泛。另一项任务是正式的记忆程序。受试者被要求学习一篇关于1954年世界杯的简短文本和事实信息，时间为10分钟。然后，他们被要求回答10个关于课文的问题，2天后，再一次，7天后。在两次测试之间，保持分数下降了，但在这项任务中，所有年龄段的坚持能力下降的程度都是相似的，因此不依赖于年龄。哌醋甲酯(10 mg P.O.)在习得后12小时，两种记忆类型的持续性显著增强。这表明多巴胺能过程参与了训练后后期的持续性。
Healthy human volunteers 16-82 years of age with at least 10 years of schooling were exposed to two different memory tasks. The first task involved incidental memory. The subjects were asked, as casually as possible: "Did you watch any movie on TV 2 days ago? And 7 days ago? If so, do you remember the title of the movie(s) and the name of the first two actors (actresses)?'' Retention scores (maximum = 3: title, actor 1, and actor 2) were equally high (overall mean = 2.6, n = 61) in all age groups (16-20, 21-30, 31-40, 41-60, and 61-82 years) for the day 2 scores. Scores for the movie seen 7 days before decreased significantly and progressively in the three older groups in relation to age, which indicates reduced persistence of this type of memory beginning at the age of 41-50 years and becoming more extensive over the years. The other task was a formal memory procedure. Subjects were asked to study a brief text with factual information on the 1954 World Soccer Cup for 10 min. They were then exposed to 10 questions on the text 2 days and, again, 7 days later. Retention scores declined between the two tests, but in this task, the decline of persistence occurred to a similar extent in all age groups, and thus was not dependent on age. Methylphenidate (10 mg p.o.) given 12 hours after acquisition markedly enhanced persistence of the two memory types. This suggests an involvement of dopaminergic processes in persistence in the late posttraining period.