Catalytic and highly regioselective cross-coupling of aromatic C-H substrates
Catalytic and highly regioselective cross-coupling of aromatic C-H substrates
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DOI：
10.1021/ja074395z
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发表时间：
2007-10-03
影响因子：
15
通讯作者：
Sanford, Melanie S.
中科院分区：
文献类型：
--
作者：
Hull, Karni L.;Sanford, Melanie S.
本通讯描述了一种新的Pd催化反应的高度化学和区域选择性的氧化交叉偶联芳香C-H键。这种转变提出通过两个离散的C-H活化步骤进行，其选择性主要由接近配体（第一C-H活化）或由芳烃C-H键周围的空间环境（第二C-H活化）控制。此外，第二C-H活化反应的选择性可以通过调节Pd中心周围的配体环境来控制。
This communication describes a new Pd-catalyzed reaction for the highly chemo- and regioselective oxidative cross-coupling of aromatic C-H bonds. This transformation is proposed to proceed via two discrete C-H activation steps whose selectivities are predominantly controlled by proximity to a ligand (first C-H activation) or by the steric environment around the arene C-H bond (second C-H activation). Furthermore, the selectivity of the second C-H activation reaction can be controlled by tuning the ligand environment around the Pd center.