Infectious complications in liver transplantation.
Infectious complications in liver transplantation.
复制标题
肝移植的感染性并发症。
作者：
J. Colonna;D. Winston;J. Brill;L. Goldstein;Marilyn P. Hoff;J. Hiatt;W. Quiñones;K. Ramming;R. Busuttil
1984年2月至1985年8月，35例患者接受了42例同种异体肝移植。23名患者(66%)在移植后的某个时间发生了一种或多种感染。每名感染患者平均发生2.5例感染。在37个细菌感染中，三分之二是细菌感染或局限性腹内感染。中位发病时间为术后29天。发现13例病毒感染，中位发病时间为术后18天。发现9例真菌感染，其中6例为播散性，3例为局限性，中位发病时间为术后9天。感染是35名患者中5名(14%)的主要死亡原因。致命性感染平均分布在细菌(两种)、真菌(三种)和病毒(两种)病原体之间。尽管外科技术和环孢素的使用取得了进步，但原位肝移植后的感染仍是一个严重的问题。某些患者可被确定为感染的高风险，需要积极的诊断检查，然后早期进行抗菌治疗。
Thirty-five patients received 42 liver homografts between February 1984 and August 1985. One or more infections developed in 23 patients (66%) some time after transplantation. An average of 2.5 infections per infected patient occurred. Of 37 bacterial infections, two thirds were either bacteremias or localized intra-abdominal infections. The median onset was 29 days after operation. Thirteen viral infections were identified, with a median onset of 18 days after operation. Nine fungal infections, six disseminated and three localized, were identified, with a median onset of nine days after operation. Infection was the primary cause of death in five (14%) of 35 patients. Fatal infections were evenly distributed among bacterial (two), fungal (three), and viral (two) pathogens. Despite advances in surgical techniques and the use of cyclosporine, infection after orthotopic liver transplantation is a serious problem. Certain patients can be identified as high risks for infection and require an aggressive diagnostic workup followed by early institution of antimicrobial therapy.
脲青霉素、氨曲南和硫霉素：作为严重感染的单一药物治疗的功效和作为联合治疗的组成部分的潜力。
DOI：
10.1093/jac/17.suppl_a.55
发表时间：
1986
期刊：
The Journal of antimicrobial chemotherapy
影响因子：
--
作者：
Winston,DJ;Ho,WG;Champlin,RE;Gale,RP;Busuttil,RW
通讯作者：
Busuttil,RW
影响因子：
0.9
作者：
Alexander,JW
通讯作者：
Alexander,JW
DOI：
10.1001/archsurg.1980.01380070009002
发表时间：
1980
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Starzl,TE;Koep,L;Porter,KA;Schroter,GP;Weil3rd,R;Hartley,RB;Halgrimson,CG
通讯作者：
Halgrimson,CG