Intratympanic dexamethasone for sudden sensorineural hearing loss: Clinical and laboratory evaluation
Intratympanic dexamethasone for sudden sensorineural hearing loss: Clinical and laboratory evaluation
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DOI：
10.1097/00129492-200101000-00005
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发表时间：
2001-01-01
影响因子：
2.1
通讯作者：
Chandrasekhar, SS
中科院分区：
文献类型：
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作者：
Chandrasekhar, SS
目的：探讨鼓室内地塞米松（IT-DEX）灌注治疗突发性感音神经性听力损失（SSNHL）的临床及动物实验价值。研究设计：回顾性分析10例经IT-DEX治疗的SSNHL患者。这些发现与该机构之前在豚鼠身上进行的一项IT-DEX研究的发现相关联。机构：门诊三级耳科转诊中心。患者：选择IT-DEX治疗的SSNHL序贯患者。干预措施：经腔注射地塞米松0.5 mg，冲洗圆窗20分钟。动物实验：79只耳朵随机分为5组：对照组、IT-DEX与静脉注射(IV)-DEX、IT-DEX与组胺、IT-DEX与透明质酸、IT-DEX与二甲亚砜。主要观察指标：临床研究：术后听力学。动物实验：淋巴周围类固醇浓度。结果：与IV-DEX相比，IT-DEX可显著改善患者的听力，并显著提高患者淋巴周围类固醇浓度。结论：IT-DEX是治疗SSNHL的合适治疗方案。对剂量和给药频率的进一步研究是必要的。
Objective: To discuss the value of intratympanic dexamethasone (IT-DEX) perfusion for sudden sensorineural hearing loss (SSNHL), clinically and in an animal model.Study Design: Retrospective case review of 10 patients with SSNHL treated with IT-DEX. The findings are correlated with this institution's previous findings from a study of IT-DEX in guinea pigs.Setting: Ambulatory tertiary otologic referral center.Patients: Sequential patients with SSNHL who chose IT-DEX treatment.Interventions: Dexamethasone 0.5 mg was injected transtympanically and bathed the round window for 20 minutes. Animal study: 79 ears were randomized into five groups: control, IT-DEX versus intravenous (IV)-DEX, IT-DEX with histamine, IT-DEX with hyaluronic acid, and IT-DEX with dimethylsulfoxide.Main Outcome Measures: Clinical study: postprocedure audiometry. Animal study: perilymph steroid concentration.Results: IT-DEX results in significant hearing improvement and in significantly higher perilymph concentration of steroid than IV-DEX.Conclusions: IT-DEX is an appropriate treatment option for the treatment of SSNHL. Further study of dosages and frequency of administration is warranted.