Optimizing Weight for Maternal and Infant Health - Tenable, or Too Late?
Optimizing Weight for Maternal and Infant Health - Tenable, or Too Late?
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DOI：
10.1586/17446651.2014.991102
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发表时间：
2015
影响因子：
3.2
通讯作者：
Barbour LA
中科院分区：
文献类型：
--
作者：
Nicklas JM;Barbour LA
妊娠期肥胖是导致母亲和胎儿发病的主要原因，而妊娠期体重增加（GWG）是改善妊娠结局的一个可改变的风险因素。大多数孕妇的体重增加超过了2009年医学研究所的建议，特别是超重和肥胖的妇女。GWG甚至低于2009年IOM肥胖妇女指南可能会改善妊娠结局并减少大胎龄（LGA）婴儿，这是儿童肥胖的独立风险因素，而不会增加小胎龄（SGA）婴儿。不幸的是，尽管已经进行了50多项旨在减少过量GWG的干预性试验，但这些干预措施的效果有限，旨在促进产后体重减轻的干预措施也令人失望。成功的干预措施不仅对改善妊娠结局至关重要，而且对母亲和婴儿未来的代谢健康也至关重要，可能是降低儿童肥胖跨代风险的关键。
Obesity in pregnancy is the leading cause of maternal and fetal morbidity, and gestational weight gain (GWG) is one modifiable risk factor that improves pregnancy outcomes. Most pregnant women gain more than the 2009 Institute of Medicine recommendations, particularly overweight and obese women. GWG even less than the 2009 IOM guidelines in obese women may improve pregnancy outcomes and reduce large-for-gestational-age (LGA) infants, an independent risk factor for childhood obesity, without increasing small-for-gestational-age (SGA) infants. Unfortunately, despite the fact that over 50 interventional trials designed to decrease excess GWG have been conducted, these interventions have been only modestly effective, and interventions designed to facilitate weight postpartum weight loss have also been disappointing. Successful interventions are of paramount importance not only to improve pregnancy outcomes but also for the future metabolic health of the mother and her infant, and may be key in attenuating the trans-generational risk on childhood obesity.