Cardiovascular Effects of Antidepressant Medications
Cardiovascular Effects of Antidepressant Medications
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抗抑郁药物对心血管的影响
DOI：
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发表时间：
1988
影响因子：
10.5
通讯作者：
J. Mann
中科院分区：
文献类型：
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作者：
James P. Halper;J. Mann
抗抑郁药与各种副作用有关，其严重程度从仅仅令人烦恼到具有显著发病率甚至潜在死亡率的那些。后者中最突出的是心血管效应，这为开发新的抗抑郁药（如氟西汀）提供了很大的动力。在本文中，我们将回顾这些心血管效应，但由于以前在其他地方已经进行过（例如Glassman & Bigger，1981;马歇尔& Forker，1882; Glassman，1984 a），我们的考虑将是选择性的，重点是与新抗抑郁药评价相关的方法学问题。由于心脏副作用的机制是最好的理解与三环类抗抑郁药（TCAs），这些将是一个主要的焦点，并将提供一个新的代理商的考虑背景。虽然对新型抗抑郁药的副作用知之甚少，但对有关其安全性的知识和观点的演变进行检查是特别相关的，因为它说明了通常伴随着新治疗药物的引入而出现的热情的起伏。我们在下面回顾了关于氟西汀和其他一些选择性抗抑郁药的数据，并讨论了氟西汀对心血管系统的作用及其对这些药物临床应用的影响。由于Risch et al（1982）和Glassman & Salzman（1987）已经综述了抗抑郁药与用于治疗心血管疾病的药物之间的相互作用，因此在此不再考虑。
Antidepressants are associated with a variety of side-effects, ranging in severity from the merely annoying to those with significant morbidity and even potential mortality. Prominent among the latter are cardiovascular effects, which have provided much of the impetus for the development of newer antidepressants such as fluoxetine. In this paper, we will review these cardiovascular effects, but as this has been previously undertaken elsewhere (e.g. Glassman & Bigger, 1981; Marshall & Forker, 1882; Glassman, 1984a), our consideration will be selective, with emphasis on methodological issues of relevance to the evaluation of new antidepressants. Since mechanisms of cardiac side-effects are best understood in relation to tricyclic antidepressants (TCAs), these will be a major focus, and will provide a background for the consideration of newer agents. While less is known regarding the side-effects of the newer antidepressants, examination of the evolution of knowledge and opinions regarding their safety is particularly pertinent in that it illustrates the waxing and waning of enthusiasm that typically accompanies the introduction of new therapeutic agents. We review below the growing body of data regarding fluoxetine and some of the other serotonin-selective antidepressants, as well as discussing serotonergic effects on the cardiovascular system and their implications for the clinical use of these agents. Since the interactions between antidepressants and drugs used to treat cardiovascular disorders have been reviewed by Risch et al (1982) and Glassman & Salzman (1987), these will not be considered here.
地昔帕明治疗期间的主要不良反应：与血浆药物浓度、伴随抗精神病药物治疗和患者特征的关系。
影响因子：
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作者：
Nelson,JC;Jatlow,PI;Bock,J;Quinlan,DM;BowersJr,MB
通讯作者：
BowersJr,MB