The small nucleolar ribonucleoprotein (snoRNP) database
The small nucleolar ribonucleoprotein (snoRNP) database
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DOI：
10.1261/rna.1871310
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发表时间：
2010-04-01
期刊：
影响因子：
4.5
通讯作者：
Brown, James W.
中科院分区：
文献类型：
--
作者：
Ellis, J. Christopher;Brown, Daniel D.;Brown, James W.
小核仁核糖核蛋白(SnoRNPs)是核糖体RNA序列特异的2‘-O-核糖甲基化和假脱氧核糖基化的指导性RNA。此外，snoRNAs还被证明与一些tRNAs相互作用，并在mRNA生物发生中直接进行选择性剪接。生物信息学的最新进展导致了能够快速识别一般非编码RNA和特定于基因组和元基因组序列的snoRNA的新算法，导致识别出的snoRNA序列的数量和多样性迅速增加。SnoRNP数据库是来自广泛物种的snoRNA和snoRNA相关蛋白质序列的网络集合。该数据库目前包含来自细菌、古生物和真核生物的8994个snoRNA序列和589个snoRNA相关蛋白序列。SnoRNP数据库可在http://evolveathome.com/snoRNA/snoRNA.php.上找到
Small nucleolar ribonucleoproteins (snoRNPs) are widely studied and characterized as guide RNAs for sequence-specific 2'-O-ribose methylation and psuedouridylation of ribosomal RNAs. In addition, snoRNAs have also been shown to interact with some tRNAs and direct alternative splicing in mRNA biogenesis. Recent advances in bioinformatics have resulted in new algorithms able to rapidly identify noncoding RNAs generally and snoRNAs specifically in genomic and metagenomic sequences, resulting in a rapid increase in the number and diversity of identified snoRNA sequences. The snoRNP database is a web-based collection of snoRNA and snoRNA-associated protein sequences from a wide range of species. The database currently contains 8994 snoRNA sequences from Bacteria, Archaea, and Eukaryotes and 589 snoRNA-associated protein sequences. The snoRNP database can be found at: http://evolveathome.com/snoRNA/snoRNA.php.