A role for the small GTPase Rac1 in vaccinia actin-based motility.
A role for the small GTPase Rac1 in vaccinia actin-based motility.
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DOI：
10.4161/sgtp.29038
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Agaisse, Herve
中科院分区：
文献类型：
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作者：
Alvarez, Diego E;Agaisse, Herve
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/FHOD1 pathway.
